A cartilage mimetic gel includes double network hydrogels. The double network hydrogels comprise a first crosslinked network and a second crosslinked network. The first crosslinked network can be formed from poly(2-acrylamido-2-methylpropane sulfonic acid). The second crosslinked network can be formed from poly(N-isopropyl acrylamide-co-acrylamide).

A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.

A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.

A medical device comprising a substantially flexible porous structure. The porous structure comprises a plurality of interlocking units. Each of the plurality of interlocking units comprises a body and at least one arm. The plurality of interlocking units is configured to have space between adjacent interlocking units when the porous structure is in a neutral configuration. The plurality of interlocking units is configured to contact the respective body and arm of adjacent interlocking units when a compressive force is applied to the porous structure, thereby restricting compression of the porous structure. The plurality of interlocking units is configured to contact the respective arms of adjacent interlocking units when an extension force is applied to the porous structure, thereby restricting extension of the porous structure.

A medical device comprising a substantially flexible porous structure. The porous structure comprises a plurality of interlocking units. Each of the plurality of interlocking units comprises a body and at least one arm. The plurality of interlocking units is configured to have space between adjacent interlocking units when the porous structure is in a neutral configuration. The plurality of interlocking units is configured to contact the respective body and arm of adjacent interlocking units when a compressive force is applied to the porous structure, thereby restricting compression of the porous structure. The plurality of interlocking units is configured to contact the respective arms of adjacent interlocking units when an extension force is applied to the porous structure, thereby restricting extension of the porous structure.

The present invention addresses the problem of providing a plasma spraying material with which it is possible to form an HAp film that has high hardness and is not susceptible to abrasion, even under conditions involving plasma spraying with low flame energy. In the present invention, an HAp powder having an average particle diameter (D.sub.50) of 15-40 μm and a pore volume of 0.01-0.30 cc/g at a pore diameter of 2000 nm or less as measured through mercury intrusion makes it possible to form an HAp film that has high hardness, is not susceptible to abrasion, and can be subjected to plasma spraying, even under conditions involving plasma spraying with low flame energy.

The present invention addresses the problem of providing a plasma spraying material with which it is possible to form an HAp film that has high hardness and is not susceptible to abrasion, even under conditions involving plasma spraying with low flame energy. In the present invention, an HAp powder having an average particle diameter (D.sub.50) of 15-40 μm and a pore volume of 0.01-0.30 cc/g at a pore diameter of 2000 nm or less as measured through mercury intrusion makes it possible to form an HAp film that has high hardness, is not susceptible to abrasion, and can be subjected to plasma spraying, even under conditions involving plasma spraying with low flame energy.

An object of the present invention is to provide a calcium phosphate powder that enables the preparation of a slurry for additive manufacturing with excellent dispersion stability, and enables the production of a three-dimensional additive manufacturing article with high strength, in additive manufacturing. Provided is a calcium phosphate powder, having an average particle size (D.sub.50) of 0.1 to 5.0 μm, and having a pore volume of mesopores (pore size: 2 to 50 nm) of 0.01 to 0.06 cc/g as measured by a gas adsorption method. The calcium phosphate powder has excellent dispersion stability in a slurry for additive manufacturing, and, by performing additive manufacturing using a slurry for additive manufacturing containing the calcium phosphate, it is possible to produce a three-dimensional additive manufacturing article with high strength, which is useful as an implant, such as an artificial bone.

An object of the present invention is to provide a calcium phosphate powder that enables the preparation of a slurry for additive manufacturing with excellent dispersion stability, and enables the production of a three-dimensional additive manufacturing article with high strength, in additive manufacturing. Provided is a calcium phosphate powder, having an average particle size (D.sub.50) of 0.1 to 5.0 μm, and having a pore volume of mesopores (pore size: 2 to 50 nm) of 0.01 to 0.06 cc/g as measured by a gas adsorption method. The calcium phosphate powder has excellent dispersion stability in a slurry for additive manufacturing, and, by performing additive manufacturing using a slurry for additive manufacturing containing the calcium phosphate, it is possible to produce a three-dimensional additive manufacturing article with high strength, which is useful as an implant, such as an artificial bone.

Methods and compositions for tissue regeneration of the present invention include a biocompatible porous composite of a decellularized tissue and an aptamer-functionalized hydrogel, wherein the aptamers of the aptamer-functionalized hydrogel specifically and reversibly bind to an active agent.