Provided herein are scaffold biomaterials including a decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed, the decellularized plant or fungal tissue having a 3-dimensional porous structure; wherein the decellularized plant or fungal tissue may optionally be at least partially coated or mineralized, wherein the scaffold biomaterial may optionally further include a protein-based hydrogel and/or a polysaccharide-based hydrogel, or both. Also provided herein are methods and uses of such scaffold biomaterials, including methods of manufacture as well as methods and uses for bone tissue engineering, for example.

The present invention relates to porous composite materials and objects such as 3D scaffolds, in particular to bioactive and bioresorbable scaffolds that can be transformed at body temperature.

The present invention relates to porous composite materials and objects such as 3D scaffolds, in particular to bioactive and bioresorbable scaffolds that can be transformed at body temperature.

A method for producing a composite demineralized bone matrix composition using a one-step process is described. The composite demineralized bone matrix composition is produced from the biologically-derived bone. In addition, the composite demineralized bone matrix composition contains bone minerals according to the original composition proportion in the bone and may provide a bone mineral content condition that is closest to that in an environment in which in vivo bone formation occurs. In addition, the composition contains a bone morphogenetic protein (BMP-2), and thus enables a stable and excellent bone formation effect to be derived.

The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.

The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.

A suture thread for use in a lifting procedure according to the present invention is characterized by comprising: fixed portions composed of non-stretchable medical thread, wherein the medical thread is formed on both sides thereof and is fixed to the skin; and a variable portion that is positioned between the fixed portions and imparts structural elasticity, wherein the fixed portions and the variable portions are connected continuously, without a separate connecting structure, to form a single integrated medical thread.

A method is used to insert an implant within a lateral wall of a nose of a patient. The method includes forming an initial incision with a surface of the lateral wall of the nose. A stylet is advanced within the lateral wall of the nose, thereby creating a pocket within the lateral wall of the nose. The stylet is further advanced until an expanding body of the stylet is at least partially housed within the pocket of the lateral wall. The expanding body of the stylet is enlarged to thereby enlarge the pocket within the lateral wall. The implant is placed within the enlarged pocket of the lateral wall.

A method is used to insert an implant within a lateral wall of a nose of a patient. The method includes forming an initial incision with a surface of the lateral wall of the nose. A stylet is advanced within the lateral wall of the nose, thereby creating a pocket within the lateral wall of the nose. The stylet is further advanced until an expanding body of the stylet is at least partially housed within the pocket of the lateral wall. The expanding body of the stylet is enlarged to thereby enlarge the pocket within the lateral wall. The implant is placed within the enlarged pocket of the lateral wall.

A system or method for bioprinting bone graft provides obtaining an image of the patient's oral facial area, and viewed with the image viewing software. A restoratively driven dental implant treatment plan is created to restore the patient's missing dentition. The restoratively driven treatment plan is created. A physical exam, review of a patient's desires and expectations, review of imaging, acquisition and review of patient photographs and intraoral digital impressions. The imaging and digital impressions are aligned, via software to create a virtual representation. The anticipated final implant retained dentures, unitary implant crowns, or implant bridges, are planned to provide optimal esthetic and functional results. Dental implants are then planned for prosthetic anchors. Bone deficiencies are evaluated and if areas of boney deficiency are present, a patient specific bone graft is designed to restore said deficient areas. Once designed, it may be printed via additive manufacturing.