An apparatus includes a body configured to be at least partially implanted on or within a recipient and a plurality of electrodes positioned along the body. The plurality of electrodes includes a first set of electrodes configured to apply electrical stimulation signals to at least a portion of the recipient. The plurality of electrodes further includes a second set of electrodes configured to apply an electric field to cell membranes of the recipient, the electric field configured to increase a permeability of the cell membranes to a substance.

An apparatus includes a body configured to be at least partially implanted on or within a recipient and a plurality of electrodes positioned along the body. The plurality of electrodes includes a first set of electrodes configured to apply electrical stimulation signals to at least a portion of the recipient. The plurality of electrodes further includes a second set of electrodes configured to apply an electric field to cell membranes of the recipient, the electric field configured to increase a permeability of the cell membranes to a substance.

The present invention relates to a biodegradable alloy of Formula (I): Mg—Zn—X, wherein X represents —Ca—Mn or —Dy—Sr, wherein Zn is about 0.1 wt % to about 3.0 wt %, Dy is about 0.1 wt % to about 0.7 wt %, Sr is about 0.1 wt % to about 0.9 wt %, Ca is about 0.1 wt % to about 1.5 wt %, Mn is about 0.1 wt % to about 0.9 wt % and Mg is balance with impurities. The present invention further relates to a method for producing alloys, wherein the method comprises: (a) placing alloy components in a crucible, wherein the alloy components are placed in the crucible in a multilayer arrangement; (b) melting the alloy components at about 700° C. to about 850° C.; (c) stirring the melt of step (b) at about 400 rpm to about 500 rpm; (d) atomizing the melt of step (c) into millimeter size droplets using jets of inert gas; and (e) cooling and depositing the atomized alloy melt to obtain an ingot.

The present invention relates to a biodegradable alloy of Formula (I): Mg—Zn—X, wherein X represents —Ca—Mn or —Dy—Sr, wherein Zn is about 0.1 wt % to about 3.0 wt %, Dy is about 0.1 wt % to about 0.7 wt %, Sr is about 0.1 wt % to about 0.9 wt %, Ca is about 0.1 wt % to about 1.5 wt %, Mn is about 0.1 wt % to about 0.9 wt % and Mg is balance with impurities. The present invention further relates to a method for producing alloys, wherein the method comprises: (a) placing alloy components in a crucible, wherein the alloy components are placed in the crucible in a multilayer arrangement; (b) melting the alloy components at about 700° C. to about 850° C.; (c) stirring the melt of step (b) at about 400 rpm to about 500 rpm; (d) atomizing the melt of step (c) into millimeter size droplets using jets of inert gas; and (e) cooling and depositing the atomized alloy melt to obtain an ingot.

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

An intraocular lenses having a plurality of drug-containing microspheres attached to the intraocular lens. The intraocular lenses can be used for patients undergoing cataract surgery and reduces the need for recurrent surgery, follow-up treatment or postoperative eye-drops. Also provides a method for manufacturing such an intraocular lens and the use of an intraocular lens in the treatment of cataract.

An intraocular lenses having a plurality of drug-containing microspheres attached to the intraocular lens. The intraocular lenses can be used for patients undergoing cataract surgery and reduces the need for recurrent surgery, follow-up treatment or postoperative eye-drops. Also provides a method for manufacturing such an intraocular lens and the use of an intraocular lens in the treatment of cataract.

Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

Described herein are compositions comprising a BMP-2 derived peptide conjugated to albumin for use in bone grafts. The composition may further include bone matrix, such as demineralized bone matrix (DBM).