The present invention concerns a hydrogel comprising hyaluronic acid (HA) or a derivative thereof, loaded with at least one positively charged antimicrobial peptide, wherein said HA or derivative thereof is cross-linked with a cross-linking agent at the level of its hydroxyl moieties while the carboxyl moieties of HA or derivative thereof remain free and said HA or derivative thereof remains negatively charged; and a method for preparing said loaded hydrogel.

The present invention concerns a hydrogel comprising hyaluronic acid (HA) or a derivative thereof, loaded with at least one positively charged antimicrobial peptide, wherein said HA or derivative thereof is cross-linked with a cross-linking agent at the level of its hydroxyl moieties while the carboxyl moieties of HA or derivative thereof remain free and said HA or derivative thereof remains negatively charged; and a method for preparing said loaded hydrogel.

In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.

In some aspects, provided herein are antimicrobial compositions comprising partially esterified polygalacturonic acid and certain fatty acids (e.g., caprylic acid). In some embodiments, the antimicrobial composition may be administered (e.g., topically or orally) to a subject, such as a human patient to treat an infection (e.g., an infection comprising a biofilm). In some aspects, improved catheters are provided.

Medical devices having an alkaline resistant halogenated polymer include a halogenated polymer incorporating one or more of a polymeric stabilizer, a polymeric plasticizer or a free radical inhibitor or combinations thereof. The medical devices can be used to administer high pH formulations to a patient in need of such administration by administering the formulation through contact the an alkaline resistant halogenated polymer.

Medical devices having an alkaline resistant halogenated polymer include a halogenated polymer incorporating one or more of a polymeric stabilizer, a polymeric plasticizer or a free radical inhibitor or combinations thereof. The medical devices can be used to administer high pH formulations to a patient in need of such administration by administering the formulation through contact the an alkaline resistant halogenated polymer.

An extension tube for a urinary catheter comprises a tubular body with an inlet opening, an outlet opening and an internal lumen extending between the inlet opening and the opening. The tubular body comprising at least a first layer, which first layer includes natural and/or regenerated cellulose fibers, and preferably to a large extent, such as at least 40 wt %. The tubular body is further arranged to be compressible into a compacted, preferably generally flat, storage state, and to be expandable into an expanded, tubular use state

A holding device for a breathing tube for use in lung function diagnostics is disclosed. This holding device consists of a material that is transparent for light having a wavelength in a first wavelength range but nontransparent for light having a wavelength in a second wavelength range. In other aspects, a lung function diagnostics device comprising such a holding device and a method for reading out a coding on a surface of a breathing tube for use in lung function diagnostics are disclosed.

Methods of making sleeved hydrophilic urinary catheters.

Hydration mediums, assemblies containing hydration mediums and methods of making the same are disclosed. The hydration mediums are intended for hydrating or wetting a medical device such as a catheter and comprise a hydration foam. Furthermore, methods and products involving hydrophilic substances are disclosed e.g. involving mucilage, deep eutectic liquids, antifreeze substances or cryoprotectants, oil or a hydration medium together with water, surfactant, polyol and stabilizer.