A biomedical device is disclosed which is a polymerization product of a mixture comprising (a) one or more difunctional isocyanates; (b) one or more polyalcohols; (c) one or more hydroxy-terminated polysiloxane prepolymers; and (d) one or more polyoxazoline polyols having a weight average molecular weight of equal to or greater than about 1000 Daltons.

A steerable catheter may include an elongate shaft member and a braided reinforcement structure embedded into a wall of the elongate shaft member. The braided reinforcement structure may include a first braided portion including a first pick count, a second braided portion including a second pick count, and a third braided portion including a third pick count. The third pick count may be greater than each of the first pick count and the second pick count.

A steerable catheter may include an elongate shaft member and a braided reinforcement structure embedded into a wall of the elongate shaft member. The braided reinforcement structure may include a first braided portion including a first pick count, a second braided portion including a second pick count, and a third braided portion including a third pick count. The third pick count may be greater than each of the first pick count and the second pick count.

In a method of integrating an active pharmaceutical ingredient (API) with a thermoplastic polymer, the thermoplastic polymer and API are into a first feed port of a multi-screw extruder or the thermoplastic polymer is fed into the first feed port of a multi-screw extruder, the thermoplastic polymer is conveyed along the heated multi-screw extruder while heating the thermoplastic polymer to a melt temperature of 160° C.-280° C. prior to the thermoplastic polymer being conveyed past a second feed port and the API is fed into the second feeding port in the heated screw extruder to mix with the melted thermoplastic polymer to generate a compounded mixture containing 85-100% of the starting API content. The compounded mixture is extruded from an outlet of the heated screw extruder and cooled via a cooling device such that the compounded mixture contains 85-100% of the starting API content.

In a method of integrating an active pharmaceutical ingredient (API) with a thermoplastic polymer, the thermoplastic polymer and API are into a first feed port of a multi-screw extruder or the thermoplastic polymer is fed into the first feed port of a multi-screw extruder, the thermoplastic polymer is conveyed along the heated multi-screw extruder while heating the thermoplastic polymer to a melt temperature of 160° C.-280° C. prior to the thermoplastic polymer being conveyed past a second feed port and the API is fed into the second feeding port in the heated screw extruder to mix with the melted thermoplastic polymer to generate a compounded mixture containing 85-100% of the starting API content. The compounded mixture is extruded from an outlet of the heated screw extruder and cooled via a cooling device such that the compounded mixture contains 85-100% of the starting API content.

In a method of integrating an active pharmaceutical ingredient (API) with a thermoplastic polymer, the thermoplastic polymer and API are into a first feed port of a multi-screw extruder or the thermoplastic polymer is fed into the first feed port of a multi-screw extruder, the thermoplastic polymer is conveyed along the heated multi-screw extruder while heating the thermoplastic polymer to a melt temperature of 160° C.-280° C. prior to the thermoplastic polymer being conveyed past a second feed port and the API is fed into the second feeding port in the heated screw extruder to mix with the melted thermoplastic polymer to generate a compounded mixture containing 85-100% of the starting API content. The compounded mixture is extruded from an outlet of the heated screw extruder and cooled via a cooling device such that the compounded mixture contains 85-100% of the starting API content.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

A medical tubing contains a thermoplastic polyurethane.

A medical tubing contains a thermoplastic polyurethane.