The disclosed medical device has high visibility on non-woven fabric having a color such as green, blue, or the like, excellent identifiability from other medical devices having colors such as green, blue, or the like, and also a high adhesion property and strength of a coating. The medical device comprises an elongated body and a resin layer covering at least a proximal portion of the elongated body. The resin layer is comprised of a first layer which includes a first fluororesin, an organic pigment and titanium oxide, and a second layer which is formed on the first layer and includes a second fluororesin.

The disclosed medical device has high visibility on non-woven fabric having a color such as green, blue, or the like, excellent identifiability from other medical devices having colors such as green, blue, or the like, and also a high adhesion property and strength of a coating. The medical device comprises an elongated body and a resin layer covering at least a proximal portion of the elongated body. The resin layer is comprised of a first layer which includes a first fluororesin, an organic pigment and titanium oxide, and a second layer which is formed on the first layer and includes a second fluororesin.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, at least in part, on the discovery that biomaterial coated with a cytokine eluting coating resulted in the shift of early stage macrophage polarization that were associated with positive long-term effects such as minimized capsule formation and improved tissue quality and composition as compared to uncoated biomaterials.

The invention discloses a photocured medical catheter hydrophilic lubricating coating and a preparation method thereof. The hydrophilic lubricating coating comprises a primer coating and a lubricating coating. The primer coating is attached to the surface of a device, and the lubricating coating is attached to the primer coating. The primer coating comprises 1-10 parts by weight of one or more polyester acrylates, 50-90 parts by weight of one or more solvents, 0.5-5 parts by weight of one or more photoinitiators, 0.5-2 parts by weight of one or more wetting agents and 0.5-5 parts by weight of one or more reactive (or active) diluents. The lubricating coating comprises 1-10 parts by weight of one or more water soluble macromolecules, 1-5 parts by weight of one or more crosslinking (or crosslinked) macromolecules, 0-1 part by weight of one or more photoinitiators, 0.1-1 part by weight of one or more surfactants and 50-98 parts by weight of one or more solvents. The preparation method of the hydrophilic lubricating coating is simple and easy in operation. Substance residues caused by complicated high-temperature chemical reactions are avoided. The cured coating forms a crosslinking (or crosslinked) structure, has good adhesion on the surface of a medical catheter and has excellent and lasting lubricity in an aqueous medium. The friction coefficient of the surface of the medical catheter is reduced. Harm to human tissues and adhesion of macromolecules in blood are decreased.

The invention discloses a photocured medical catheter hydrophilic lubricating coating and a preparation method thereof. The hydrophilic lubricating coating comprises a primer coating and a lubricating coating. The primer coating is attached to the surface of a device, and the lubricating coating is attached to the primer coating. The primer coating comprises 1-10 parts by weight of one or more polyester acrylates, 50-90 parts by weight of one or more solvents, 0.5-5 parts by weight of one or more photoinitiators, 0.5-2 parts by weight of one or more wetting agents and 0.5-5 parts by weight of one or more reactive (or active) diluents. The lubricating coating comprises 1-10 parts by weight of one or more water soluble macromolecules, 1-5 parts by weight of one or more crosslinking (or crosslinked) macromolecules, 0-1 part by weight of one or more photoinitiators, 0.1-1 part by weight of one or more surfactants and 50-98 parts by weight of one or more solvents. The preparation method of the hydrophilic lubricating coating is simple and easy in operation. Substance residues caused by complicated high-temperature chemical reactions are avoided. The cured coating forms a crosslinking (or crosslinked) structure, has good adhesion on the surface of a medical catheter and has excellent and lasting lubricity in an aqueous medium. The friction coefficient of the surface of the medical catheter is reduced. Harm to human tissues and adhesion of macromolecules in blood are decreased.

An apparatus for harvesting a subcutaneous blood vessel is disclosed. The apparatus comprises a guidewire with an angled tip, an intra-vascular catheter to receive the guidewire and having a lateral orifice to allow the angled tip thereof to perforate the subcutaneous blood vessel. The apparatus further comprises a flexible pulling device having a pair of circumferential grooves, one adjacent to each end thereof, to allow for securing the subcutaneous blood vessel thereat; and a flexible pushing device having a concave-cup shape at a distal end thereof to facilitate pushing of the subcutaneous blood vessel secured with one of the pair of circumferential grooves of the flexible pulling device. The flexible pulling device and the flexible pushing device are operable in conjunction to cause inversion and eversion and separation from the surrounding tissues of the subcutaneous blood vessel for removal and harvesting thereof.

Embodiments provided herein include methods, compositions, and uses of aromatic alcohols to increase the potency of antifungal agents.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

This invention disclosed medical catheters with surface hydrophilic coatings. Said catheters were grafted with a thin layer of zwitterions, which forms lubricious water layer when contacted with human body liquids or other water solutions, to lower the surface friction and mechanical damage to human body. One benefit of the present invention is due to the excellent biocompatibility and tight bonding between modification material and catheter substrate, the modification will stably stay on the substrate during usage, to avoid the potential side effects caused by lubricants. This modification can be applied to multiple material surfaces, including but not limited to silicone rubber, polyurethane, rubber, polyetheretherketone, polyethylene, polypropylene, polyvinyl chloride, nylon, ABS (Acylonitrile Butadiene Styrene), and polycarbonate.