An endoscopic coating composition including a solid lubricant, a fluorine-containing surfactant, a thermosetting resin, and a solvent, a lubricating member provided by a coating treatment using the coating composition and being suitable as an endoscopic member, a method for producing the lubricating member, and an endoscopic flexible tube and an endoscope including the lubricating member.

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

Antimicrobial metal ion coatings. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal.

The present disclosure relates to multilayer coatings that include a hydrophobic encasing layer and allow controlled release of a water soluble drug. The encasing layer encases water soluble, or hydrophilic, drugs with a flexible layer and comes in good intimate contact with the water soluble drug layer. Thus, the encasing layer conforms to the water soluble drug and can control the release of the drug. Advantageously, major cuts or fissures in the coating do not cause the water soluble drug to leak or burst out; rather, the encasing layer continues to provide modulated release of the drug. The present disclosure also includes methods of making the multilayer coatings, methods of using the multilayer coatings, and articles that include the multilayer coatings.

Synthesis methods for creating polymeric compounds comprising phenyl derivatives (PD), or PDp i.e., polymers modified with PD, with desired surface active effects are described. The polymer backbone of PDp has structural or performance features that can be tailored to control physical properties of PDp, allowing it to be useful for different applications i.e., tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.

A ureteral catheter structure, comprising a catheter body (1). The catheter body (1) comprises a stepped braided tube (2), a bending tube (3), and a plastic catheter tip (14) which are spliced with each other. A first stainless steel outer tube (4) supports and connects the stepped braided tube (2) and the bending tube (3) at a splice therebetween, and a first PET heat-shrinkable film (5) is coated on the first stainless steel outer tube (4). A second stainless steel outer tube (6) supports and connects the bending tube (3) and the plastic catheter tip (14) at a position therebetween, and a second PET heat-shrinkable film (7) is coated on the second stainless steel outer tube (6). A traction wire (8) is provided within the catheter body (1), an end of the traction wire (8) being fixed on the bending tube (3), while the other end passing through the stepped braided tube (2). A heat-shrinkable sleeve (9) is provided outside the bending tube (3). An end of the ureteral catheter may be independently bent in multiple sections, thereby achieving a good detection effect, and solving the technical problem of instability when an end of the ureteral catheter is deflected.

A ureteral catheter structure, comprising a catheter body (1). The catheter body (1) comprises a stepped braided tube (2), a bending tube (3), and a plastic catheter tip (14) which are spliced with each other. A first stainless steel outer tube (4) supports and connects the stepped braided tube (2) and the bending tube (3) at a splice therebetween, and a first PET heat-shrinkable film (5) is coated on the first stainless steel outer tube (4). A second stainless steel outer tube (6) supports and connects the bending tube (3) and the plastic catheter tip (14) at a position therebetween, and a second PET heat-shrinkable film (7) is coated on the second stainless steel outer tube (6). A traction wire (8) is provided within the catheter body (1), an end of the traction wire (8) being fixed on the bending tube (3), while the other end passing through the stepped braided tube (2). A heat-shrinkable sleeve (9) is provided outside the bending tube (3). An end of the ureteral catheter may be independently bent in multiple sections, thereby achieving a good detection effect, and solving the technical problem of instability when an end of the ureteral catheter is deflected.

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.