Invasive medical devices including a substantially non-eluting antimicrobial treatment are disclosed. One or more external and/or internal surfaces of the medical device include a substantially non-eluting copper-coated surface that assists in preventing microbial colonization of the coated surface. This in turn reduces the incidence of infection to the patient originating from the medical device. In one embodiment, a catheter assembly is disclosed and comprises an elongate catheter tube that defines at least one lumen, at least one extension leg including a luer connector, and a bifurcation hub including at least one fluid passageway that provides fluid communication between the extension leg and the lumen. A substantially non-eluting copper coating is disposed on a surface of at least one of the lumen, the extension leg, the luer connector, and the fluid passageway. The coating is applied via an electroless deposition process. A water-shed coating is disposed on the copper coating.

Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

Therapeutic compositions, primarily for topical application, and methods of making and using the composition. Pharmaceutical compositions formulated for specific forms of administration are also provided.

Certain embodiments are directed to methods and compositions for inhibiting, stabilizing or preventing fungal infections by yeast on a surface using an agent comprising one or more types of quantum dots sufficient to regulate the growth of fungal cells or biofilms thereof.

Hydration solutions including a liquid and a volatile solute, assemblies containing hydration solutions and methods of making the same.

The present disclosure generally relates to implantable devices including a releasable nitrite ion and to methods of preparing and using such compositions and devices. In one embodiment, the device is a stent, for example, a vascular stent. In another embodiment, the nitrite ion is ionically bound to an inorganic ion.

An elongate body extending from a proximal end to a distal end includes a core comprising an amorphous metal alloy and includes a sheath that comprises a crystalline metallic material. The sheath surrounds the core.

Provided are formulations and related methods, for coating or impregnating a medical device, as well as a coated or impregnated medical device, for example, a device that is a catheter or cannula, where a different formulation may be used for interior surface of device and for exterior surface of the device.

An antimicrobial catheter assembly can include a hub, a catheter tube connected to the hub, at least one extension leg connected to the hub, and a non-eluting antimicrobial coating on an internal or external surface of the catheter assembly. The hub includes at least one hub lumen defining a corresponding hub portion of a fluid pathway through the catheter assembly. The catheter tube includes at least one catheter-tube lumen defining a corresponding catheter-tube portion of the fluid pathway through the catheter assembly. The extension leg can include an extension-leg lumen defining a corresponding extension-leg portion of the fluid pathway through the catheter assembly. The antimicrobial coating can include a copper-based layer between a corrosion-preventing layer and the internal or external surface of the catheter assembly, an adhesion-promoting layer between the copper-based layer and the internal or external surface of the catheter assembly, or a combination thereof.