Thermoplastic elastomer compositions can be used for medical skin contact applications, comprising: a) 90.9 to 69.0 wt.-% star-shaped block copolymer A with 4 arms of the general structure [S.sub.1—(S/B).sub.k—(S/B).sub.I—(S/B).sub.m—S.sub.2].sub.n—X, where S.sub.1 and S.sub.2 are vinylaro-matic hard polymer and S/B are soft random vinylaromatic/diene copolymer blocks; X is a coupling center; and b) 9.1 to 31.0 wt.-% of a plasticizer B: b1) a mixture of mineral oil B1 and cyclohexane 1,2-dicarboxylic acid C.sub.8 to C.sub.10 dialkyl ester B2; or b2) a mixture of mineral oil B1 and vegetable oil B3.

Described herein are nitric oxide releasing materials, methods of making nitric oxide releasing materials, and devices including nitric oxide releasing materials. The nitric oxide releasing material includes a polymer matrix having a plurality of polysiloxanes and nitric oxide-donating crosslinking moieties that covalently crosslink the polysiloxanes. Blood clotting or adhesion of a bio-material to a surface, as well as biofilm formation can be prevented using the methods and materials described.

A preparation method comprises following steps: S1: dissolving a coupling agent in an ethanol solution, adding an ultrafine radiopaque agent powder in the ethanol solution, and obtaining a modified ultrafine radiopaque agent powder by agitation, washing and drying, the ultrafine radiopaque agent powder having a particle size of 0.35-0.8 μm; S2: obtaining the radiopaque material by mixing a medical polymeric material with the modified ultrafine radiopaque agent powder. A prepared radiopaque material exhibits not only radiopaque functions but also good mechanical properties of improved elastic modulus, fracture strength and bending modulus, thereby expanding application of medical polymer hollow fibers in high-end medical products for minimally invasive intervention. Particularly, delivery devices applied with prepared radiopaque material have improved pushing and torque performance and are suitable for ultra-smooth guidewires, heart valve prostheses, guiding catheters, and degradable balloons.

A preparation method comprises following steps: S1: dissolving a coupling agent in an ethanol solution, adding an ultrafine radiopaque agent powder in the ethanol solution, and obtaining a modified ultrafine radiopaque agent powder by agitation, washing and drying, the ultrafine radiopaque agent powder having a particle size of 0.35-0.8 μm; S2: obtaining the radiopaque material by mixing a medical polymeric material with the modified ultrafine radiopaque agent powder. A prepared radiopaque material exhibits not only radiopaque functions but also good mechanical properties of improved elastic modulus, fracture strength and bending modulus, thereby expanding application of medical polymer hollow fibers in high-end medical products for minimally invasive intervention. Particularly, delivery devices applied with prepared radiopaque material have improved pushing and torque performance and are suitable for ultra-smooth guidewires, heart valve prostheses, guiding catheters, and degradable balloons.

The invention relates to a rod-shaped body comprised of one or more filaments and of a non-ferromagnetic matrix material. The matrix material surrounds the filament(s) and/or adheres them to one another. The rod-shaped body is also comprised of a dopant consisting of particles that generate magnetic resonance tomographic artifacts that is introduced into the matrix material. Rod-shaped bodies of this type can be used to construct guide wires, catheters and other instruments to be used in minimally invasive surgical interventions.

A polymeric tubular conduit including a polymeric tubular conduit wall having an outer tubular layer coaxially overlaying an inner tubular layer which defines a continuous tubular passage along a polymeric tubular conduit length of the polymeric tubular conduit; whereby the outer tubular layer, the inner tubular layer, or combinations thereof, include an amount of antimicrobial agent. The amount of antimicrobial agent can be sufficient to kill or inhibit growth of microorganisms in contact with a corresponding polymeric tubular conduit wall external surface, polymeric tubular conduit wall internal surface, or combinations thereof, of the polymeric tubular conduit wall.

There is provided silicone rubber that achieves both a low modulus and high tear strength and a liquid silicone rubber composition that gives the silicone rubber. The liquid silicone rubber composition contains: (A) an alkenyl group-containing linear polyorganosiloxane; (B) a 0.1 to 39 parts by mass linear hydrogenorganopolysiloxane relative to 100 parts by mass of (A); (C) a polyorganosiloxane having alkenyl groups and Si—H whose total number in one molecule is three or more; (D) a hydrosilylation catalyst; and (E) a silica powder having a specific surface area of 100 to 420 m.sup.2/g, the content of the silica powder being 10 to 50 parts by mass relative to 100 parts by mass of (A). Relative to the total mass of (A), (B), and (C), the total molar amount of the alkenyl groups of (A) and Si—H of (B) is 0.03 to 0.19 mmol/g, and the total molar amount of the alkenyl groups and SiH of (C) is 0.01 to 0.05 mmol/g. An Si—H/alkenyl group ratio of the composition is 0.7 to 1.3.

There is provided silicone rubber that achieves both a low modulus and high tear strength and a liquid silicone rubber composition that gives the silicone rubber. The liquid silicone rubber composition contains: (A) an alkenyl group-containing linear polyorganosiloxane; (B) a 0.1 to 39 parts by mass linear hydrogenorganopolysiloxane relative to 100 parts by mass of (A); (C) a polyorganosiloxane having alkenyl groups and Si—H whose total number in one molecule is three or more; (D) a hydrosilylation catalyst; and (E) a silica powder having a specific surface area of 100 to 420 m.sup.2/g, the content of the silica powder being 10 to 50 parts by mass relative to 100 parts by mass of (A). Relative to the total mass of (A), (B), and (C), the total molar amount of the alkenyl groups of (A) and Si—H of (B) is 0.03 to 0.19 mmol/g, and the total molar amount of the alkenyl groups and SiH of (C) is 0.01 to 0.05 mmol/g. An Si—H/alkenyl group ratio of the composition is 0.7 to 1.3.

Tubing, such as medical tubing for administration of intravenous fluid, can include an outer layer on an inner layer, and, optionally additional layers, in which at least the outer layer and the inner layer are made of a same polymeric material but the outer and inner layers have differing amounts or differing types of a plasticizer such that a hardness of the outer layer is greater than a hardness of the inner layer.

In one embodiment, a visually clear or transparent and manually flexible medical tube (10) adapted for in vivo transport of an aqueous fluid to a subject comprising an inner layer (3), a middle layer (2) and an outer layer (1), wherein the inner layer (3) comprises a polypropylene, the outer layer (1) comprises a thermoplastic polyurethane or a cyclic olefin copolymer, and the middle layer (2) is selected from one or more of ethylene vinyl acetate copolymers, ethylene acrylate copolymers, ethylene-acrylate maleic anhydride terpolymers, ethylene-acrylate glycidyl methacrylate terpolymers, and maleic anhydride grafted polypropylene.