The present invention is silver (I) periodate compounds and their use in preventing or reducing microbial contamination. The invention includes gels, coatings, and articles of manufacture having a surface contacted or coated with a gel comprising an antimicrobial silver (I) compound. Methods of treatment are also disclosed.

A medical device including a substrate and a hydrophilic polymer layer and satisfying the following conditions: (1) that the hydrophilic polymer layer is on at least a part of the substrate; (2) that the hydrophilic polymer layer contains: a hydrophilic polymer having an acidic group; and a compound having an acidic group and a ring structure; and (3) that a time during which a liquid film is retained on the surface of the medical device (a liquid film retention time) is 10 seconds or more after the medical device is stationarily immersed in a phosphate buffer solution, pulled up from the phosphate buffer solution, and retained in the air. The present invention provides a medical device in which a surface of a substrate is hydrophilized, and a method for manufacturing same by a simple method.

The present invention relates to coatings for devices such as medical devices that are useful for coating a variety of different types of material surfaces, including polymer and metal surfaces. The present invention also includes the method of using the coated device and methods to make the coated device and coating.

A method for delivering a therapeutic agent to a tumor through a target vessel includes delivering the therapeutic agent through a lumen of a catheter which has been coated or otherwise structured to reduce the wall shear stress during delivery of the immunotherapy and by generating turbulent flow during the delivery of the therapeutic agent.

The invention relates to medical devices and production thereof. The medical device may be a tubular medical device and has a high biocompatibility e.g. for use as implant. The medical tubular device may have a body structure extending from a first end to a second end of the medical tubular device and having a luminal surface and an external surface, wherein the body structure comprises an interpenetrating polymer network (IPN) comprising a host polymer matrix and at least one hydrogel guest polymer domain of a guest polymer, which is interpenetrating the host polymer matrix.

Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

The compositions of the present invention comprise at least one medium polarity oil and at least one antibacterial agent, the combination of which produces a synergistic antibacterial effect against bacterial biofilms. Methods are disclosed for the reduction of bacteria in and/or elimination of bacterial biofilms on biological and non-biological surfaces, as well as methods for the treatment of wounds, skin lesions, mucous membrane lesions, and other biological surfaces infected or contaminated with bacterial biofilms.

Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.

The present invention concerns a hydrogel comprising hyaluronic acid (HA) or a derivative thereof, loaded with at least one positively charged antimicrobial peptide, wherein said HA or derivative thereof is cross-linked with a cross-linking agent at the level of its hydroxyl moieties while the carboxyl moieties of HA or derivative thereof remain free and said HA or derivative thereof remains negatively charged; and a method for preparing said loaded hydrogel.

Gel compositions for use as a barrier for microbial attachment and growth on a surface are provided. The gel compositions can prevent crystal formation, for example, calcium-based stones in biological systems. The gel compositions can enhance function of mucosal barriers against microbial adhesion. Specific compositions for anti-bacterial and anti-viral use are provided.