A urinary catheter (10, 110) having a porous tip region (26, 22a, 22b, 22c, 126).

The present invention provides materials and methods for forming an interface between an appliance and living tissue using a foamed elastomeric material which contacts the tissue or similar surfaces. The elastomeric material is in the form of a durable and washable material that when applied to living tissue or similar surfaces displaces and flows in to non-conforming areas creating an air and/or water tight seal that substantially returns to an original shape when removed from the contact surface. The appliance may also include structural elements designed to optimize comfort, compliance and seal achieved through minimizing the pressure variation along the contact surface of the therapy device.

The present disclosure provides tubing comprising porous fluoropolymers for use in non-medical and medical applications along with methods of making the tubing. Also described are medical devices including catheters and shunts comprising the tubing. Specifically, a catheter, cannula, drain, shunt, or totally implantable venous access port comprising a section of tubing with at least two lumens separated by septa, as well as an outer wall and a fluorinated liquid. Wherein the outer wall and the septa are a porous fluoropolymer and the fluorinated liquid is absorbed into the pores of both the septa and the outer wall of the tubing.

The present disclosure relates to drug eluting devices, and their uses. The drug eluting devices can allow for perfusion during deployment. The coatings the may contain bioactive materials which elute once deployed in a patient and can have anti-proliferative, anti-inflammation, or anti-thrombotic effects. Sol gel technology can be used to coat the devices.

A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.

A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.

The present invention provides improved drug-eluting tube devices. In some embodiments, the tube devices deliver analgesics directly at sites of internal discomfort, including, but not limited to, internal membranes and implant entry sites. In some embodiments, the tube devices can be reloaded with drug in situ. In some embodiments, the tube devices comprise lubricating coatings to reduce painful friction with internal membranes. In some embodiments, the tube devices further include flexible and pliable regions that dampen force transmission to implanted sites, such as by inadvertent pulling.

A tubular working channel sheath that includes a working channel, a first sheath layer that defines the working channel and includes at least one plastic material. The first sheath layer has a constant layer thickness along an entire length of the working channel. The tubular working channel sheath includes a second sheath layer that includes at least one further plastic material different than the plastic material of the one sheath layer. The second sheath layer has a tapered layer thickness along a length of the working channel, and the tapered layer thickness tapers between a proximal end and a distal end of the working channel.

A flushable catheter having an outer wall defining an inner conduit and an inner core member positioned within the inner conduit. The inner core being made from flushable materials, which are preferably degradable water soluble materials such that the inner core degrades as urine or water pass through the inner conduit defined by the outer wall.

Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.