According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.

According to the invention there is provided inter alia a medical device for delivering a paclitaxel to a tissue, the device the device having a coating layer applied to a surface of the device, the coating layer comprising components i), ii) and iii), wherein component i) is a therapeutic agent which is paclitaxel; and component ii) is urea or a pharmaceutically acceptable salt thereof, or a urea derivative or a pharmaceutically acceptable salt thereof; and component iii) is succinic acid, glutaric acid or caffeine, or a pharmaceutically acceptable salt of any one thereof.

The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

Systems and methods for biofilm inoculation including a feeding tube having a distal end for placement in the gut of a patient, and a biofilm coated or otherwise provided on the distal end of the feeding tube for introducing the biofilm to the gut of the patient. In example embodiments, the biofilm can be colostrum, breast milk or one or more probiotics.

Systems and methods for biofilm inoculation including a feeding tube having a distal end for placement in the gut of a patient, and a biofilm coated or otherwise provided on the distal end of the feeding tube for introducing the biofilm to the gut of the patient. In example embodiments, the biofilm can be colostrum, breast milk or one or more probiotics.

An infusion catheter includes a housing, a proximal shaft assembly, a first distal shaft assembly and a second distal shaft assembly. The housing has one or more inflation ports and one or more infusion ports. The proximal shaft assembly supports a first balloon. The first distal shaft assembly extends distally from the proximal shaft assembly and supports a first distal balloon. The second distal shaft assembly extends distally from the proximal shaft assembly and supports a second distal balloon. The first and second distal shaft assemblies define infusion openings in fluid communication with the one or more infusion ports. The infusion catheter may be inserted into a uterine cavity to occlude tubal ostia and an internal cervical OS of the uterine cavity for sealing the uterine cavity. A therapeutic agent may be delivered through the infusion catheter and into the sealed uterine cavity to treat the uterine cavity.

An infusion catheter includes a housing, a proximal shaft assembly, a first distal shaft assembly and a second distal shaft assembly. The housing has one or more inflation ports and one or more infusion ports. The proximal shaft assembly supports a first balloon. The first distal shaft assembly extends distally from the proximal shaft assembly and supports a first distal balloon. The second distal shaft assembly extends distally from the proximal shaft assembly and supports a second distal balloon. The first and second distal shaft assemblies define infusion openings in fluid communication with the one or more infusion ports. The infusion catheter may be inserted into a uterine cavity to occlude tubal ostia and an internal cervical OS of the uterine cavity for sealing the uterine cavity. A therapeutic agent may be delivered through the infusion catheter and into the sealed uterine cavity to treat the uterine cavity.

In a medical instrument that is inserted into an affected area or tissue to perform treatment, a technique of delivering various drugs to a target site is desired.

Provided is a medical instrument that is inserted into an affected area or tissue to perform treatment, wherein a drug-loaded nanostructure is covalently bound to the medical instrument via a photosensitive linker immobilized on the surface of at least a portion of the medical instrument.