A parison for being blow molded into a medical balloon for a catheter includes a first tubular layer having a functional modification and a second tubular layer adapted for bonding with the first tubular layer to form the blow molded balloon. Related methods are also disclosed.

A parison for being blow molded into a medical balloon for a catheter includes a first tubular layer having a functional modification and a second tubular layer adapted for bonding with the first tubular layer to form the blow molded balloon. Related methods are also disclosed.

Medical devices are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

Medical devices are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.

An intravascular blood pump (P) comprises a catheter (5) and a pumping device (1) attached to a distal end (15) of the catheter (5). The blood pump (P) is advanced through a patient's blood vessel by means of the catheter (5). The catheter (5) has an elongate tubular body (10) and a porous three-dimensional structure (6) provided on at least a portion of the outer surface (8) of the catheter body (10) to promote adsorption of proteins and formation of an autologous graft (7) to prevent the catheter (5) from growing into the inner wall of the blood vessel. The porous three-dimensional structure (6) may be formed as a textile sleeve (6), preferably made of a warp knitted fabric.

An intravascular blood pump (P) comprises a catheter (5) and a pumping device (1) attached to a distal end (15) of the catheter (5). The blood pump (P) is advanced through a patient's blood vessel by means of the catheter (5). The catheter (5) has an elongate tubular body (10) and a porous three-dimensional structure (6) provided on at least a portion of the outer surface (8) of the catheter body (10) to promote adsorption of proteins and formation of an autologous graft (7) to prevent the catheter (5) from growing into the inner wall of the blood vessel. The porous three-dimensional structure (6) may be formed as a textile sleeve (6), preferably made of a warp knitted fabric.

A pharmaceutical composition is described. The pharmaceutical composition includes a polymeric coating composition comprising polymeric nanoparticles dispersed within a polymeric matrix, wherein the polymeric nanoparticles include a first therapeutic agent and a second therapeutic agent. Implantable medical devices coated with the pharmaceutical composition, methods of coating an implantable medical device with the pharmaceutical composition, and methods of treating vascular disease using the pharmaceutical composition are also described.

A parison for being blow molded into a medical balloon for a catheter includes a first tubular layer having a functional modification and a second tubular layer adapted for bonding with the first tubular layer to form the blow molded balloon. Related methods are also disclosed.

Medical devices that are formed from a polymeric matrix including a first polymer and a functionalized polymer are provided. The medical devices may include a functionalized polymer such as maleic anhydride functionalized polymer. The burst strength and/or the hoop strength of the medical devices including the functionalized polymer may be greater than the burst strength and/or the hoop strength of control medical devices. However, the durometer of the medical devices may be substantially equal to the durometer of the control medical devices. Methods of manufacturing medical devices including a functionalized polymer are also provided.

Medical devices that are formed from a polymeric matrix including a first polymer and a functionalized polymer are provided. The medical devices may include a functionalized polymer such as maleic anhydride functionalized polymer. The burst strength and/or the hoop strength of the medical devices including the functionalized polymer may be greater than the burst strength and/or the hoop strength of control medical devices. However, the durometer of the medical devices may be substantially equal to the durometer of the control medical devices. Methods of manufacturing medical devices including a functionalized polymer are also provided.