The pharmaceutical composition constituted by carboxymethylated starch and citric acid, a citrate, or mixtures thereof, prevents adhesion of injured mesothelial surfaces and the formation of adhesion bands between the mesothelia at the highest level. The composition in gel form acts as a matrix in which connective tissue healing of tissue defects is promoted.

The pharmaceutical composition constituted by carboxymethylated starch and citric acid, a citrate, or mixtures thereof, prevents adhesion of injured mesothelial surfaces and the formation of adhesion bands between the mesothelia at the highest level. The composition in gel form acts as a matrix in which connective tissue healing of tissue defects is promoted.

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide abroad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide abroad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.

A staple cartridge comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises an external layer and tubular elements. The tubular elements are interconnected and positioned within the external layer. The tubular elements comprise apertures defined therein and the tubular elements are configured to collapse as pressure is applied to the tissue thickness compensator by tissue during the firing motion. The apertures enable fluids from the tissue to permeate the tissue thickness compensator.

A staple cartridge comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises an external layer and tubular elements. The tubular elements are interconnected and positioned within the external layer. The tubular elements comprise apertures defined therein and the tubular elements are configured to collapse as pressure is applied to the tissue thickness compensator by tissue during the firing motion. The apertures enable fluids from the tissue to permeate the tissue thickness compensator.

The present invention relates, in general terms, to methods of reducing the formation of post-surgery tissue adhesion in a subject in need thereof by administering an adhesion barrier composition. The present invention also relates to methods of preventing the formation of tissue adhesion during or post-surgery in a subject in need thereof. The adhesion barrier composition comprises sporopollenin and a biodegradable polymer. The present invention also relates to methods of fabricating the adhesion barrier composition.

Implantable scaffolds that treat solid tumors and escape variants and that provide effective vaccinations against cancer recurrence are described. The scaffolds include genetically-reprogrammed lymphocytes and a lymphocyte-activating moiety.

A method of treating a lesion in a gastrointestinal tract and an injectate system are provided. The method includes injecting a crosslinkable gel into a first tissue layer, the crosslinkable gel increasing a volume of the first tissue layer. The method also includes providing a crosslinker and resecting a portion of a first tissue layer having the increased volume away from a second tissue layer creating an exposed region in a remaining portion of the first layer and leaving a portion of the gel covering at least a portion of the exposed region. The injectate system includes a crosslinkable gel and a crosslinker where the crosslinkable gel and the crosslinker form a crosslinked gel having a compressive modulus of about 10-500 kPa.

A surgical device includes a substrate and a first coating that covers at least a portion of the substrate. The first coating includes a first polymer. The first coating having antibiotics dispersed in the first polymer such that the first polymer releases the antibiotics as the first polymer degrades. A second coating covers at least a portion of the first coating. The second coating includes a second polymer. The second coating has ellagic acid dispersed in the second polymer such that the second polymer releases the ellagic acid as the second polymer degrades. In some embodiments, systems and methods are disclosed.