An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate and a hemostatic agent. The substrate includes a first piece and a second piece that is joined with the first piece. The first piece includes the hemostatic agent and the second piece includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed.

The present invention provides alginic acid derivatives having a group represented by general formula (I) or general formula (II) (the right side of the dashed line is excluded in each formula) at a portion of the carboxyl groups in an alginic acid. Novel alginic acid derivatives are thereby provided. ##STR00001##

The present invention provides alginic acid derivatives having a group represented by general formula (I) or general formula (II) (the right side of the dashed line is excluded in each formula) at a portion of the carboxyl groups in an alginic acid. Novel alginic acid derivatives are thereby provided. ##STR00001##

An embodiment of the present invention is to provide a bioabsorbable medical material having adhesiveness to a biological tissue and improved degradability. A bioabsorbable medical material according to an embodiment of the present invention contains a crosslinked polymer material forming a specific shape, and a disintegration delaying material retained by the crosslinked polymer material. The crosslinked polymer material has degradability in water, the degradability being suppressed in the presence of an acid. The disintegration delaying material releases 0.5 mol%/day or greater of an acid until the seventh day upon contact with water at 37° C.

The invention concerns the treatment of bioprosthetic tissues a Cyclodextrin, preferably in association with Ethanol.

In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto tissue, including supporting tissues (e.g., ligaments, connective tissue, muscles, etc.) for pelvic organs, among other tissues. In other aspects, the present disclosure pertains to compositions that are useful for performing such procedures. In still other aspects, the present disclosure pertains to kits that are useful for performing such procedures.

Biologically acceptable surgical barrier materials are comprised of a polyelectrolytic complex of chitosan and sodium alginate. The chitosan is deacetylated in an amount between about 40 to about 60% and has a molecular weight (Mw) between 50,000 and 375,000 g/mol. The barrier materials may be formed by mixing a two-component material system whereby one component comprises the chitosan and a second component comprises the sodium alginate and directing such a mixture (e.g., via air-assisted spray nozzle) toward a surgical site in need of the material. A polyelectrolytic complex of the chitosan and sodium alginate will thereby form in situ. Suitable ionic cross-linkers may be provided in the individual components, e.g., calcium chloride with the chitosan component and sodium tripolyphosphate with the sodium alginate component.

Biologically acceptable surgical barrier materials are comprised of a polyelectrolytic complex of chitosan and sodium alginate. The chitosan is deacetylated in an amount between about 40 to about 60% and has a molecular weight (Mw) between 50,000 and 375,000 g/mol. The barrier materials may be formed by mixing a two-component material system whereby one component comprises the chitosan and a second component comprises the sodium alginate and directing such a mixture (e.g., via air-assisted spray nozzle) toward a surgical site in need of the material. A polyelectrolytic complex of the chitosan and sodium alginate will thereby form in situ. Suitable ionic cross-linkers may be provided in the individual components, e.g., calcium chloride with the chitosan component and sodium tripolyphosphate with the sodium alginate component.

A double-layered medical membrane and a method for manufacturing the same are provided. The double-layered medical membrane includes a hydrophilic material layer and a hydrophobic material layer disposed thereon. The hydrophilic material layer includes hydrophilic fibers, hydrophilic particles, or a combination thereof. The hydrophilic fibers and the hydrophilic particles include a hydrophilic polymer as a material. The method includes the following steps: using an electrospinning solution to form the hydrophilic material layer by electrospinning or using a hydrophilic solution to form the hydrophilic material layer; and producing the double-layered medical membrane that includes the hydrophilic material layer. The hydrophilic material layer includes the hydrophilic fibers, the hydrophilic particles, or the combination thereof. The hydrophilic fibers or the hydrophilic particles include the hydrophilic polymer as a material.

A double-layered medical membrane and a method for manufacturing the same are provided. The double-layered medical membrane includes a hydrophilic material layer and a hydrophobic material layer disposed thereon. The hydrophilic material layer includes hydrophilic fibers, hydrophilic particles, or a combination thereof. The hydrophilic fibers and the hydrophilic particles include a hydrophilic polymer as a material. The method includes the following steps: using an electrospinning solution to form the hydrophilic material layer by electrospinning or using a hydrophilic solution to form the hydrophilic material layer; and producing the double-layered medical membrane that includes the hydrophilic material layer. The hydrophilic material layer includes the hydrophilic fibers, the hydrophilic particles, or the combination thereof. The hydrophilic fibers or the hydrophilic particles include the hydrophilic polymer as a material.