The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.

An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.

An implantable medical device and methods for making and using the same are provided. In various embodiments, the device comprises a central hub structure in communication with at least one housing or pod capable of containing cells and therapeutic materials. Also provided are membrane structures and methods of forming the same, the membranes comprising a gradient of varying porosity for use with devices of the present disclosure, as well as other uses.

A method for forming a material in an in situ medical device by initiating polymerization of water soluble polymer precursors in an aqueous solution during or after transport of the polymerizable solution from its storage container to a space inside the in situ medical device is described. The stored aqueous solution with water soluble precursors lacks a free radical initiator which, in a powder form, is introduced into the aqueous solution during or after its transport into the space inside the in situ medical device. This storage and delivery system provides greater stability to the stored aqueous solution, allowing it to be stored at ambient temperature and providing extended shelf life over the solutions used in existing in situ polymerization systems. The flexibility to store and deliver/transport only one aqueous solution, instead of requiring the use of two different solutions, is also a benefit.

A longitudinal extending body with oriented fibers comprised of an organic compound, preferably cellulose fibers, with a hydrophilic and hydrophobic polymer having absorbable and non res sorbable qualities in the body, with an internal construction to promote cell growth. The longitudinal body has at least one wall having oriented fiber to include cellulose fiber extending the length of said body. This extending body has a surface that is smooth to the touch for additional processing methods such as machining, compression molding and 3 D printing.

Systems and methods for soft tissue to bone repairs, without knot tying. The soft tissue repair systems include self-cinching constructs with a fixation device, a flexible coupler and an optional shuttle/pull device attached to the flexible strand. An accordion-style weave region is formed by pulling on the shuttle/pull device subsequent to the fixation device being secured into the bone, to allow desired tensioning of soft tissue to be fixated or repaired relative to the bone and secured self-locking of the construct.

A surgical membrane for supporting bone growth comprises a surface configured for receiving a surface functionalisation agent capable of promoting cell adhesion and proliferation and/or of reducing bacterial growth on said surface. The membrane is also subjected to a treatment improving the wettability of the surface.

A surgical membrane for supporting bone growth comprises a surface configured for receiving a surface functionalisation agent capable of promoting cell adhesion and proliferation and/or of reducing bacterial growth on said surface. The membrane is also subjected to a treatment improving the wettability of the surface.

A surgical staple comprising a substrate and one or more coatings which slows the bioabsorption of the substrate. The coating can be selected so as to affect the environment surrounding the staple once the staple is implanted in the patient. The effect on the environment can cause the bioabsorption to occur within a desired time frame.

Disclosed herein are drug delivery devices that can temporally and spatially deliver biologically active agents. An example drug delivery device includes a microneedle array comprising a plurality of microneedles on a surface of a substrate, each microneedle comprising a core comprising a hydrogel and a layer on a surface of the core. Also disclosed are methods of using the drug delivery device, and methods of making the microneedle array that includes a loading device.