A biomaterial that includes collagen and an antimicrobial agent such as citric acid is provided herein. The biomaterial may further include a metal, such as silver, and an anionic polysaccharide, such as oxidized regenerated cellulose (ORC). Methods of using the biomaterial in wound therapy and on medical implants, and methods for preparing the biomaterial are also disclosed herein.

A coating layer, for example PEEK or titanium foil, shields a bone implant surface from wearing interactions with surfaces of bone and/or other implants. The coating prevents shedding particles which are difficult to distinguish from evidence of potentially dangerous conditions, for example, microorganism contamination and/or degenerating tissue. Methods and structures for securing a coating layer are described. Other uses and implementations of coating layers are described.

The present invention improves the surface modification of NiTi alloys used for instance in medical devices through treatment with hydrogen particles in a suitable gaseous discharge and with oxygen atoms. The technique according to the present invention provides the formation of biocompatible solely titanium oxide layer thus preventing nickel to be present in the top surface layer. Furthermore this enables nanostructuring of the surface which depends on the treatment conditions. Devices made from NiTi alloys treated with the method according to the present invention have improved biocompatibility; platelets do not readily attach and activate on such surfaces and the thrombus formation rate is reduced in comparison with extensively used untreated NiTi alloys.

An entirely or partially implantable medical product with a negatively charged surface for repulsing bacteria has a superficially bonded substance with a permanently negative excess charge, which substance is inert against cells of the human body and the bacteria contained therein.

A surface coating for a medical instrument includes an interference filter having at least one dielectric layer and at least one metallic layer arranged one above another. At least one of the at least one metallic layer and the at least one dielectric layer is adapted to be structurally altered by action of a corrosive environment on the surface coating such that the surface coating is convertible from a first state to a second state. In the first state, the surface coating has a first spectral reflectivity. In the second state, the surface coating has a second spectral reflectivity that is different from the first spectral reflectivity.

The disclosed medical device has high visibility on non-woven fabric having a color such as green, blue, or the like, excellent identifiability from other medical devices having colors such as green, blue, or the like, and also a high adhesion property and strength of a coating. The medical device comprises an elongated body and a resin layer covering at least a proximal portion of the elongated body. The resin layer is comprised of a first layer which includes a first fluororesin, an organic pigment and titanium oxide, and a second layer which is formed on the first layer and includes a second fluororesin.

A device (1) with a stent structure (2) wherein the stent structure (2), preferably at its proximal end, is connected to an insertion aid (3), and wherein the device (1) is deployable for the treatment of a vasospasm and the stent structure (2) is designed so as to be detachable from the insertion aid (3), with at least portions of the stent structure (2) being provided with a coating and this coating comprising a functional layer, with said functional layer containing at least one sugar alcohol and/or being formed by an oligo- or polymerization of monosaccharides functionalized with polymerizable groups. Furthermore, the invention also relates to a relevant method for the treatment of vasospasms.

The present invention relates to a method for mineralising a biopolymer membrane, comprising the following steps: a) Introduction of an assembly (3) constituted of a biopolymer membrane (4) comprised between two cellulose sheets (A) and (B), in a vessel comprising: a first compartment (1) and a second compartment (2), each comprising an electrode, a first electrode being an anode placed in the first compartment (1) and a second electrode being a cathode placed in the second compartment (2), the walls of the first compartment (1) and the second compartment (2) brought into contact with one another each having an opening placing in communication the first and the second compartments,
the assembly (3) being arranged in said opening between the first and the second compartments in such a way as to close it, the cellulose sheet (A) being on the side of the first compartment (1) and the cellulose sheet (B) on the side of the second compartment (2), b) filling the first compartment (1) with an aqueous solution containing at least one cation chosen from: calcium ions, silver ions, zinc ions, copper ions, sodium ions, magnesium ions and aluminium ions, and the second compartment (2) with an aqueous solution containing at least one anion chosen from fluoride ions, sulphate ions, carbonate ions, silicate ions and phosphate ions; c) application of an electrical voltage between the electrodes; d) turning over the assembly (3) in such a way that the cellulose sheet (A) is on the side of the second compartment and the cellulose sheet (B) on the side of the first compartment, or exchange of the solutions and electrodes of the first and the second compartments; c) application of an electrical voltage between the electrodes, said voltage being equal to that applied at step (c) and being applied for a duration identical to that of step (c); e) removal and rinsing of the assembly (3); f) recovery and drying of the mineralised biopolymer membrane.

The invention includes compositions including magnesium-lithium alloys containing various alloying elements for medical implant devices. The devices are constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also includes methods of preparing the magnesium-lithium alloys and articles, such as medical implant devices, for use in medical applications, including orthopedic, dental, craniofacial and cardiovascular surgery.

A silicone septum having a surface coating. The coated silicone septum may be incorporated in an intravenous catheter assembly. The coating reduces static charge among a plurality of vibrating silicone septa during manufacture of the intravenous catheter assembly. The surface coating includes a coating agent selected from a bicarbonate salt and a siloxane polyalkyleneoxide copolymer. The bicarbonate salt may be an alkali metal bicarbonate. The siloxane polyalkyleneoxide copolymer may include copolymer groups selected from ethyleneoxide, octamethylcyclotetrasiloxane, and mixtures thereof. The silicon septum may be coated by contacting an exterior surface of the silicone septum with a coating solution of a solvent and the coating agent for at least 5 minutes. The coating agent has a concentration in the solvent greater than 1 wt. %. Excess coating solution is removed from the exterior surface of the silicone septum. The exterior surface is dried to remove the solvent, forming the surface coating.