Provided are an alginate dialdehyde-functionalized material, an alginate dialdehyde-modified material, and preparation methods therefor. Further provided is use of the above materials and methods in the manufacture of antibacterial, antifungal, and antiviral protective products. Raw materials used and the preparation methods are simple, economical, environmentally friendly and easy to scale up, have high inhibitory activity against bacteria, fungi and viruses and have great application potential in the fields of biology, medicine, health, etc.

Provided are an alginate dialdehyde-functionalized material, an alginate dialdehyde-modified material, and preparation methods therefor. Further provided is use of the above materials and methods in the manufacture of antibacterial, antifungal, and antiviral protective products. Raw materials used and the preparation methods are simple, economical, environmentally friendly and easy to scale up, have high inhibitory activity against bacteria, fungi and viruses and have great application potential in the fields of biology, medicine, health, etc.

Methods of altering the surface energy of components of a mesh nebulizer are provided, comprising: a) depositing a metal surface layer on surfaces of the component; b) forming a hydrophobic coating layer comprising an organo-silicon or a self-assembled monolayer of an organophosphorus acid directly on the metal surface layer or indirectly on the metal surface layer through an intermediate organometallic coating; and either: i) removing select areas of the hydrophobic coating layer to expose the metal surface layer; or ii) forming a polymeric coating layer chemically bonded to and propagated from terminal functional groups on the hydrophobic coating layer that are capable of initiating polymer growth when exposed to a source of polymerizable monomer, on select areas of the components. Mesh nebulizers formed by such methods are also provided.

Methods of altering the surface energy of components of a mesh nebulizer are provided, comprising: a) depositing a metal surface layer on surfaces of the component; b) forming a hydrophobic coating layer comprising an organo-silicon or a self-assembled monolayer of an organophosphorus acid directly on the metal surface layer or indirectly on the metal surface layer through an intermediate organometallic coating; and either: i) removing select areas of the hydrophobic coating layer to expose the metal surface layer; or ii) forming a polymeric coating layer chemically bonded to and propagated from terminal functional groups on the hydrophobic coating layer that are capable of initiating polymer growth when exposed to a source of polymerizable monomer, on select areas of the components. Mesh nebulizers formed by such methods are also provided.

Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.

A medical device includes a body defining an exterior surface, and a coating including a therapeutic agent-containing nanoparticle disposed on the exterior surface of the medical device. The nanoparticle may include a brush-arm star polymer. The therapeutic agent may be paclitaxel.

A medical device includes a body defining an exterior surface, and a coating including a therapeutic agent-containing nanoparticle disposed on the exterior surface of the medical device. The nanoparticle may include a brush-arm star polymer. The therapeutic agent may be paclitaxel.

A coating for a medical device is described. The coating comprises: a surface layer; and optionally a base layer; wherein the surface layer comprises a polymer chain attached to an anti-clotting group, wherein the anti-clotting group is selected from a sulfonic acid group, a sulfonamide group, a sulfamic acid group, a hydrogen sulfate group and a conjugate base thereof. Also described is a medical device comprising the coating, and uses and methods involving the coating and the medical device.