A device for endovascular treatment to ameliorate aneurysm recurrences by deploying a treatment mesh having a plurality of vertically oriented elongated support reinforcement elements that are substantially parallel and oriented upon a plane in communication with the mesh. Upon deployment, the array of distal ends of the support extensions and reinforcements are substantially oriented upon a plane, which plane is in substantially the same orientation as the opening of the aneurysm into which the device was deployed. The treatment mesh may incorporate a coating of hydrogel, optionally impregnated with pharmaceutical compounds.

An objective of the present invention is to provide an adhesion prevention material having improved barrier performance. The objective is achieved by a solid or semi-solid adhesion prevention material comprising a bioabsorbable material, said adhesion prevention material containing, as an active ingredient, a cytostatic factor demonstrating cell proliferation inhibiting effect.

New stretchable electrically conductive composite materials comprising at least one polymer and a plurality of nanoparticles are provided, which exhibit high conductivity even at high strain levels. The composite may comprise polyurethane as the polymer and spherical gold nanoparticles. Such materials have conductivity levels as high as 11,000 Scm.sup.1 at 0% strain and 2,400 Scm.sup.1 at 110% strain. Furthermore, certain embodiments of the composite have a maximum tensile strain of 480% while still exhibiting conductivity of 35 Scm.sup.1. The inventive materials are highly flexible, highly conductive and suitable for a variety of applications, especially for advanced medical devices, implants, and flexible electronics. The disclosure also provides methods of making such stretchable electrically conductive nanocomposites, including formation by layer-by-layer and vacuum assisted flocculation. In certain embodiments, stretchable chiral plasmonic composite materials for use as optic devices and methods for making them are provided.

The invention relates to the field of biotechnology and medicine, more precisely, to manufacturing technique of implantable medical devices (stents) containing organic lanthanum compound-based X-ray contrast agents distributed within the coating. The objective of this invention is the development of a biocompatible (and biodegradable) polymeric coating with glycolane on the surface of polymeric biodegradable vascular stents and other polymeric implants, which ensures, by means of introduction into a stent, satisfactory radiopacity both during stent installation in a patient and after installation, with a simultaneous additional positive effect provided by therapeutic properties of glycolane.

Composite material screws and construction techniques are described comprising reinforcing fibers directed in different winding directions and/or angles at different layers (radial depths) of the screw. Optionally, the screw comprises composite material layers wound with fibers at both the pitch of the thread of the screw and at a steeper pitch (for example, about 45). Optionally, an outer layer of the screw comprises a relative radiolucent construction and/or material, with a more radiopaque construction and/or material positioned underneath the outer layer such that at least a portion of the screw outline is delineated by a radioimaging technique (for example, fluoroscopy, CT, or MRI), while maintaining a sufficiently artifact-free image around the screw that the image characteristics of the surrounding tissue are still determinable.

Composite material screws and construction techniques are described comprising reinforcing fibers directed in different winding directions and/or angles at different layers (radial depths) of the screw. Optionally, the screw comprises composite material layers wound with fibers at both the pitch of the thread of the screw and at a steeper pitch (for example, about 45). Optionally, an outer layer of the screw comprises a relative radiolucent construction and/or material, with a more radiopaque construction and/or material positioned underneath the outer layer such that at least a portion of the screw outline is delineated by a radioimaging technique (for example, fluoroscopy, CT, or MRI), while maintaining a sufficiently artifact-free image around the screw that the image characteristics of the surrounding tissue are still determinable.

A method for coating a medical implant applies at least one coating to at least one surface of the implant by plasma polymerization. The implant has pores sized in the nanometer range. The method stabilizes the pores. The plasma polymerization is conducted in the presence of a coating gas and oxygen. A coating parameter can be selected so that a rough surface of the implant is coated. An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.

The present disclosure relates to the field of endovascular treatment. More particularly, the present invention uses a modified hydrogel intrasaccular occlusion device designed to implement an endovascular treatment to ameliorating or eliminating aneurysm recurrence, which hydrogel may optionally be impregnated with pharmaceutical compounds. The present invention also teaches the use of thin hydrogel coatings to ameliorate endovascular treatment related difficulties.

An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.

This disclosure relates to methods and compositions for managing vascular conditions by targeting microRNA. In certain embodiments, the disclosure relates to antisense, RNA interference, and blocking oligonucleotide therapeutic compositions and uses related thereto.