Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.

An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.

Staple cartridge assemblies for use with surgical stapling instruments and methods for manufacturing the same are provided. Scaffolds for use with a surgical staple cartridge and methods for manufacturing the same are also provided.

The present disclosure relates to the technical field of biomedical materials, more particularly to a degradable magnesium alloy in-situ composite anastomotic staple and a preparation method thereof. The anastomotic staple, with a composite structure, is mainly composed of Mg—Zn—Nd magnesium alloy with high strength and good plasticity (internal part), and corrosion-resistant MgF.sub.2 (external part), and is formed by in-situ synthesis of MgF.sub.2 with the outer layer of Mg—Zn—Nd magnesium alloy anastomotic staple. The magnesium alloy composite anastomotic staple provided by the present disclosure has good plastic deformation ability and mechanical strength, a low degradation rate, and a high biosafety level, which can meet the in-vivo implantation requirements. In addition, it can gradually degrade in vivo after achieving the medical effects in vivo, avoiding a second operation for removal.

Described herein are polymeric particles configured for intravascular delivery of pharmaceutical agents, e.g., to a diseased site, and methods of forming and using same. Preparation of these polymer particles is also described.

Disclosed are new classes of diphenol compounds, derived from tyrosol or tyrosol analogues, which are useful as monomers for preparation of biocompatible polymers. Also disclosed are biocompatible polymers prepared from these monomeric diphenol compounds, including novel biodegradable and/or bioresorbable polymers of formula ##STR00001## These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic compositions. The invention also provides methods for preparing these monomeric diphenol compounds and biocompatible polymers.

An implantable medical device may comprise an elongated tubular body having a scaffolding forming a plurality of cells. A polymeric covering may be disposed over at least a portion of the stent. The covering may include a plurality of voids formed in an outer surface thereof. An extracellular matrix material coating may be disposed over the polymeric covering and within the plurality of voids.

A heat treatment method for improving the mechanical property and the biofunctional stability of a magnesium alloy is provided, comprising: (1) fully annealing an original cold-drawn magnesium alloy AZ31; (2) polishing a surface of the magnesium alloy AZ31 from the step (1) by a waterproof abrasive paper; (3) heating the magnesium alloy AZ31 obtained from the step (2) to a temperature of 330° C. to 350° C. and keeping the temperature for 3 to 4 hours; and (4) cooling the magnesium alloy AZ31 obtained from the step (3) to room temperature. A method for manufacturing a small-peptide-coated biomaterial and an application of the small-peptide-coated biomaterial are further provided.

The present invention relates to a zinc-containing medical device, including a zinc-containing matrix and a polylactic acid coating arranged on the zinc-containing matrix. The polylactic acid coating has a thickness of x μm; and when x and the weight-average molecular weight Mn (kDa) of polylactic acid satisfied the following formula:

[00001]$\begin{array}{c}\left(-b+\sqrt{b^2-4ac}\right)\\ \end{array}/\begin{array}{c}\\ 2a\end{array}-2\le x\le \begin{array}{c}\left(-b+\sqrt{b^2-4ac}\right)\\ \end{array}/\begin{array}{c}\\ 2a\end{array}+2,$

the corrosion rate of zinc in the matrix is relatively small, sufficient mechanical properties can be maintained within the repair period, and the biological risk is relatively low. When the polylactic acid is poly-racemic lactic acid, a=0.0336 ln(Mn)−0.1449, b=−0.472 ln(Mn)+2.1524, and c=1.1604 ln(Mn)−5.7128; and when the polylactic acid is poly-L-lactic acid, a=−0.006 ln(Mn)+0.03441, b=0.0648 ln(Mn)−0.3662, and c=−0.162 ln(Mn)+0.7847.

A soluble needle (100) for hair transplantation, wherein the soluble needle (100) comprises a fixing plate (30) and a plurality of micro-needles (20) made of water-soluble polymers arranged on the fixing plate (30), wherein each of said micro-needle (20) comprises a needle wall (21) to penetrate scalps and a needle cavity (22) confined by the needle wall (21) and configured for accommodating a hair follicle. A method of manufacturing a soluble needle (100) for hair transplantation, wherein the method includes: dissolving water-soluble polymers in water to prepare a molding solution (S101); delivering the molding solution into a mold (S102); letting the molding solution settle in the mold to shape (S103); and separating and removing the mold to produce the soluble needle (S104). The soluble needle (100) effectively shortens the time of surgery, reduces the pain of the patients, and increases the viability rate of transplanted hair follicles.