The present disclosure relates to methods of preparing personalized blood vessels, useful for transplantation with improved host compatibility and reduced susceptibility to thrombosis. Also provided are personalized blood vessels produced by the methods and use thereof in surgery.

A biological component adhesion-suppressing material includes a substrate provided with a functional layer having, fixed on a surface thereof that comes into contact with a biological component, a polymer including a saturated aliphatic monocarboxylic acid vinyl ester unit, wherein: when compositional analysis is performed on the surface of the functional layer using a TOF-SIMS device, the number of carbon atoms in an aliphatic chain representing an ion signal detected for saturated aliphatic carboxylic acid is 2-20; and an XPS measurement taken of the surface of the functional layer shows a peak derived from an ester group.

Intraocular pressure sensors, systems, and methods of use. Implantable intraocular pressure sensing devices that are hermetically sealed and adapted to wirelessly communicate with an external device. The implantable devices can include a hermetically sealed housing, the hermetically sealed housing including therein: an antenna in electrical communication with a rechargeable power source, the rechargeable power source in electrical communication with an ASIC, and the ASIC in electrical communication with a pressure sensor.

An apparatus for use in a surgical procedure for delivering a prosthetic implant comprises a flexible sleeve configured with a first end and a second end, the flexible sleeve being tapered such that a width of a region at the second end is relatively smaller than a width of a region at the first end, and an interior surface of the flexible sleeve that form an interior cavity, the interior cavity being sized to receive the prosthetic implant; one or more surface active coatings are applied to the interior cavity. The flexible sleeve is manipulatable such that when the prosthetic implant is positioned within the interior cavity, a manually applicable directional pressure in the direction of the second end causes the prosthetic implant to extrude from the second end.

An apparatus for use in a surgical procedure for delivering a prosthetic implant comprises a flexible sleeve configured with a first end and a second end, the flexible sleeve being tapered such that a width of a region at the second end is relatively smaller than a width of a region at the first end, and an interior surface of the flexible sleeve that form an interior cavity, the interior cavity being sized to receive the prosthetic implant; one or more surface active coatings are applied to the interior cavity. The flexible sleeve is manipulatable such that when the prosthetic implant is positioned within the interior cavity, a manually applicable directional pressure in the direction of the second end causes the prosthetic implant to extrude from the second end.

The present invention provides mannose-binding lectin (MBL)-based compositions, and methods of using the MBL-based compositions in the reduction of unintended platelet activation, such as during a medical procedure.

Disclosed and claimed is any one of long-dwelling body lumen apparatus, such as a catheter or stent (c/s), said c/s comprising: at least one lumen fittingly disposed within a tubular member; a scaffold circumferentially disposed around at least one of an outer surface of at least the tubular member; said scaffold radially extending for at least a portion of the length of the at least tubular member. Furthermore, the scaffold comprised of any one of a pattern of interlocking struts with individual well-like reservoirs disposed; each reservoir having a depth sufficient enough to house at least a first agent of any one of a chemical moiety, each of the reservoirs capped to form an enclosure; and wherein a delayed degradation of said cap results in a sudden release of the housed at least first agent. Any number of agents, reservoirs, and cap configurations may be possible.

Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.

The invention relates to a heparin-functionalized semi-permeable membrane comprising at least one layer of porous biocompatible polymer, and one layer of non-woven biocompatible polymer wherein said heparin is covalently bound to a layer on the surface of said porous biocompatible polymer.

There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.