To Provide is a polymer having high antithrombogenicity compared to a conventional polymer having a glycerol group and suitable as a medical device material. It is the polymer having a structural unit derived from a glycerol group-containing monomer, and a structural unit derived from an unsaturated monomer having a structure in which an organic group having a structure site having 4 or more carbon atoms continuously bound is bound to an ethylenically unsaturated group; and satisfying a glass-transition temperature of 10 C. or less and/or a glass-transition temperature of 25 C. or less at a saturated water content.

To Provide is a polymer having high antithrombogenicity compared to a conventional polymer having a glycerol group and suitable as a medical device material. It is the polymer having a structural unit derived from a glycerol group-containing monomer, and a structural unit derived from an unsaturated monomer having a structure in which an organic group having a structure site having 4 or more carbon atoms continuously bound is bound to an ethylenically unsaturated group; and satisfying a glass-transition temperature of 10 C. or less and/or a glass-transition temperature of 25 C. or less at a saturated water content.

Methods for applying layers to medical devices and related devices are provided. Such devices can include stents. For example, the device can include a sidewall and a plurality of pores in the sidewall that are sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the tubular member is positioned in a blood vessel and adjacent to the aneurysm. The device can have an anti-thrombogenic outer layer distributed over at least a portion of the device.

New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

There is provided a copolymer for suppressing protein adsorption, which contains a constitutional unit (a) represented by Formula 1 and a constitutional unit (b) represented by Formula 2, and which is used for producing an article that comes in contact with a protein. In the formula, R.sup.1 represents a hydrogen atom or a methyl group, R.sup.2 represents an OR.sup.33, a halogen atom, COR.sup.34, COOR.sup.35, CN, CONR.sup.36R.sup.37, or R.sup.38, where R.sup.33 to R.sup.37 each independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted non-aromatic heterocyclic group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group, or a substituted or unsubstituted organosilyl group, and R.sup.38 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group. ##STR00001##

There is provided a copolymer for suppressing protein adsorption, which contains a constitutional unit (a) represented by Formula 1 and a constitutional unit (b) represented by Formula 2, and which is used for producing an article that comes in contact with a protein. In the formula, R.sup.1 represents a hydrogen atom or a methyl group, R.sup.2 represents an OR.sup.33, a halogen atom, COR.sup.34, COOR.sup.35, CN, CONR.sup.36R.sup.37, or R.sup.38, where R.sup.33 to R.sup.37 each independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted non-aromatic heterocyclic group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group, or a substituted or unsubstituted organosilyl group, and R.sup.38 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group. ##STR00001##

Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressure (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transporation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating environments.

The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressure (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transporation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating environments.