A polyester coacervate capable of disrupting biofilms formed on substrates and methods of treating contaminated substrates to disrupt and remove biofilms using polyester coacervates without the need for antibiotic therapies or mechanical disruption. The polyester coacervate exhibits tunable viscosity, hydrophobic/hydrophilic, and interfacial properties to disrupt and remove a broad range of biofilms formed on a broad range of substrates.

Described are antibiotic compositions effective against Gram-negative bacteria, the compositions comprising a polymyxin in combination with a tunicamycin or a modified tunicamycin, optionally in combination with a -lactam antibiotic. Use of these compositions to kill or inhibit Gram-negative bacteria, treat Gram-negative bacterial infections, or disinfect objects or surfaces are described.

A method of lamellar corneal graft implantation is disclosed herein. The method includes the steps of: (i) forming one or more intrastromal incisions in a cornea of an eye of a patient; (ii) removing a cut portion of the cornea defined by the one or more intrastromal incisions from the eye of the patient; (iii) applying laser energy to a lamellar corneal graft using an excimer laser so as to modify the refractive power of the lamellar corneal graft, the lamellar corneal graft being in the form of a autologous corneal graft or a homologous corneal graft; and (iv) implanting the lamellar corneal graft into the eye of the patient in a location previously occupied by the cut portion of the cornea so as to correct the refractive power of the eye of the patient.

Aspects of the disclosure relate to storage assemblies including at least part of a delivery device and an implant. The storage assemblies are configured to trap sterilizing ethylene oxide gas using its high water solubility and converting the escaped ethylene oxide to less detrimental ethylene glycol and ethylene chlorohydrin to protect the implant from damage. In one example, the storage assembly includes an inner container housing the implant and sterilizing fluid and an outer container positioned over the inner container, wherein the outer container is at least partially filled with aqueous water. The implant may be a prosthetic heart valve. Aspects of the disclosure also relate to methods of sterilizing the storage assemblies of the disclosure.

Disclosed are compositions developed for the denaturation of respiratory allergens, such as mite, pollen, feline, canine, mold and fungal allergens. In particular, disclosed are water based compositions of vegetable origin, which prevent allergic reactions in the body by denaturing respiratory allergens before they enter the body through the respiratory tract, while they are still in the environment. Different versions of compositions are disclosed containing at least one acid, at least one herbal essential oil, an anionic surfactant or cyclodextrin, as well as water.

The invention provides a method of microbial control in water comprising adding to the water one or more bromine-based biocide(s) and cis-2-decenoic acid or a salt thereof. Compositions in the form of liquid concentrates comprising bromine-based biocides and cis-2-decenoic acid or a salt thereof are also described.

The present invention relates to freshening compositions, devices comprising same and methods of using and manufacturing same. A freshening composition of the present invention comprises (i) from about 0.1 wt % to about 95 wt % perfume raw material and (ii) from about 0.01 wt % to about 90 wt % fragrance release modulator. Some freshening compositions further comprise a solvent and/or an ingredient having a functional activity. Disclosed are passive and active air or surface freshening devices comprising a freshening composition that allow controlled and customized release of the freshening composition or of a component thereof into or onto an environment. The addition of a fragrance release modulator to formulate a freshening composition of the present invention allows for modulation of the release of the freshening composition or of a component thereof.

Methods and systems for sterilizing medical devices. An illustrative method of sterilizing a medical device may comprise placing the medical device in a sterilization chamber, locking a door of the sterilization chamber, and performing one or more steps of a sterilization procedure. The one or more steps of the sterilization procedure may comprise exposing the medical device to a sterilant and monitoring a concentration of the sterilant and/or a by-product of the sterilization procedure. After the sterilization procedure is complete the door of the sterilization chamber may be unlocked when the concentration of the sterilant and/or the by-product of the sterilization procedure is below a predetermined threshold.