This invention provides a method of sterilising an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.

A reprocessing case may be used to assist in reprocessing an instrument, such as an endoscope in an automated reprocessor. The reprocessing case may include various features such that the case may include and be transitioned between a closed configuration, an open configuration, and a disinfection configuration. In particular the reprocessor may transition the case to a disinfection configuration during a reprocessing procedure.

Methods for sterilizing a substrate with radiation and radiation sterilized substrates.

Disclosed herein are methods for pasteurizing or sterilizing architectural coating compositions using elevated heat dynamically with or without pressure.

SYSTEM, METHOD AND PROCESS FOR DISINFECTION OF INTERNAL SURFACES IN ASEPTIC TANKS AND PIPELINES BY FLOODING WITH SANITIZING FOG in facilities designed to store liquids in general, such system comprising an external equipment with means to generate sanitizing fog, controlling means of gases flow rate, in-line detectors and draining means of gases inside the tank, input means of fog carrying means comprising inert gases. Disinfection process comprises introduction of a sanitizing fog with droplets with a maximum size of 10 m, preferably with maximum size of 5 m, simultaneously with removal of gases enclosed inside such tanks and pipelines, maintaining a positive pressure inside such tanks and pipelines, such method providing reduction of oxygen concentration inside the tanks in two steps, the first one comprising reduction to near 10% and the second a reduction to a value below 1%, filling the tank with a sanitizing fog during the second step.

A device and method is disclosed for assembling a container holder in a clean environment, aseptically adding a solution to a primary container, inserting the primary container into the container holder, applying a first barrier to the container holder, sterilizing the container holder comprising the primary container and the applied first barrier to provide a sterilized container holder, assembling a fluid path module in a clean environment, the assembling comprising applying a second barrier to a first end of the sterilized fluid path module, sterilizing the fluid path module to provide a sterilized fluid path module and assembling a delivery device comprising the sterilized container holder and the sterilized fluid path module.

A method of packaging pre-filled medical devices is disclosed. The method comprises producing a packaging having a front panel and a back panel defining a compartment capable of holding one or more medical devices wherein at least one of the front panel or top panel has a portion containing a gas permeable material while the remaining portion of the pouch is gas impermeable. This gas permeable material allows gas to pass through the material and contact the one or more articles contained within the compartment or allows gas to pass through the gas permeable material from the inside of the compartment to the outside of the container. Upon completion of sterilization, the pouch is sealed and the gas permeable portion is cut away leaving the sterilized medical device enclosed in a completely gas impermeable pouch.

This invention provides a method of sterilizing an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.

Leak-resistant Kits for releasably retaining a medical suction tube, e.g. a Yankauer Suction Instrument used to collect biological fluids during a medical procedure and method of use is described. The leak-resistant Kit comprises an apparatus that includes a leak proof solid bottom portion, a hollow cavity reservoir, and a top portion with a leak resistant flexible retaining disk. The flexible retaining disk functions to releasably hold, releasably retain or releasably restrict the undesired movement of a Yankauer Suction Instrument after being inserted into the disk. In addition, the flexible retaining disk functions as a splash guard for preventing biological fluids from being ejected from the reservoir. The leak-resistant Kit allows the user the ability to use one hand to manipulate a Yankauer Suction Instrument. Additionally, the apparatus fits onto a movable bracket that can also be used with one hand.

A package for an object includes a support element with a coupler configured to hold the object captive in a given orientation of the object, and release the object by pivoting the object. The support element alone defines a first chamber containing the object, the support element also includes at least two parts that can be coupled and uncoupled relative to each other by inter-fitting with partial overlap, so as to form the first chamber containing the object. A stopper is coupled to the support element of the object by inter-fitting with partial overlap such that the support element presents a grip portion that projects from the stopper. A cover is coupled to the stopper by inter-fitting with partial overlap so as to cooperate with the stopper to define a second chamber inside which the grip portion of the support element extends, and while the cover is coupled to the stopper, a grip portion of the stopper projects from the cover.