Methods of sterilizing biologics or biological components are disclosed wherein the biologic or biological component in solution or suspension form are formed using an annealing step during freeze drying so that a porous solid matrix which allows penetration of a sterilizing gas such as EtO to pass through. The annealing process decreases the particle size of lyophilized material as compared to other methods and provides a more uniform cake that is easy to reconstitute. In addition, the resulting lyophilized material made with the annealing step allows better penetration of the sterilizing gas for more effective and uniform sterilization of the material.

An UV-C device may include several UV-C light sources (e.g., UV-C LEDs) and such UV-C LEDs may have UV-C reflecting structures arranged to direct UV-C in a particular direction and at a particular size and shape. Doing so may, for example, increase the UV-C in a particular direction or working area. A UV-C generating device may be utilized in an air stream, such as an air duct, to sterilize air from that air stream. Multiple UV-C inactivation devices may be coupled in series and placed into a single housing for in order to increase the efficacy of the UV-C inactivation device. The inlet of the device may draw air using an inlet module attachment (e.g., a hood with one or more than one inlet hood) and may output air using an outlet module attachment (e.g., a duct to deliver air to an outflow air duct). Computational fluid dynamic software may be provided where UV-C inactivation devices may be positioned (e.g., manually or autonomously by an adaptive algorithm) to determine impact on airflow against various pathogens (e.g., Staphylococcus and/or SARS-CoV-2).

Systems are disclosed which are programmed to receive data regarding a quantity and/or type of at least a subset of a plurality of disinfection sources for disinfecting an area or room and determining, based on the received data, operating parameter/s for one or more disinfection sources to disinfect the area or room. In addition, systems are disclosed which facilitate power redirection among multiple disinfection sources upon detecting a given area has received a predetermined dose of ultraviolet light. Furthermore, a method is disclosed which includes determining a schedule of locations to position a disinfection apparatus in a room or area to successively disinfect identified objects and/or surfaces in the room that are arranged between 2 and 4 feet from a floor of the room/area and tailoring one or more operating parameters of the disinfection apparatus to primarily disinfect the target objects and/or surfaces at each of the scheduled locations.

An apparatus for steam treating cannabis is provided, the apparatus comprising: a steam manifold (1) that is adapted to receive steam from a steam source and to distribute steam to a plurality of lances, the lances being configured to deliver steam into the interior volume of a batch of cannabis (10); a temperature sensor for sensing a temperature of the batch of cannabis, and a controller. The controller is configured to receive a signal from the temperature sensor (27), and to control the supply of steam to the lances to raise the temperature of the cannabis to a target temperature. A method of steaming cannabis is also provided.

A process for providing a sterilized dental article, at least a portion of the surface of which exhibiting a contact angle of less than 45°. The process includes the subsequent steps of a) providing a dental article and b) subjecting the initial dental article to a hydrogen peroxide plasma treatment. It is characterized in that the hydrogen peroxide plasma sterilization treatment of step b) is carried out in the presence of a carbon-containing compound, which during treatment is converted to form a carboxylic group attached to the surface of the dental article.

A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

The invention relates to a biocompatible molded part for supporting new bone formation, in particular the reformation of a jaw bone or a jaw bone portion in a mammal, preferably a human, wherein the molded part is suitable to be placed on the jaw bone and is designed as a solid body. The invention also relates to a composition for producing a biocompatible molded part, a method for producing a biocompatible molded part, a use of a biocompatible molded part and a kit comprising a plurality of molded parts.

Ultraviolet radiation is directed within an area. Items located within the area and/or one or more conditions of the area are monitored over a period of time. Based on the monitoring, ultraviolet radiation sources are controlled by adjusting a direction, an intensity, a pattern, and/or a spectral power of the ultraviolet radiation generated by the ultraviolet radiation source. Adjustments to the ultraviolet radiation source(s) can correspond to one of a plurality of selectable operating configurations including a storage life preservation operating configuration, a disinfection operating configuration, and an ethylene decomposition operating configuration.

The present invention concerns a tissue-engineered medical device, as well as a method for the production said medical device, comprising the following steps: providing a polymer scaffold comprising a mesh comprising polyglycolic acid, and a coating comprising poly-4-hydroxybutyrate; application of a cell suspension containing preferably human cells to the polymer scaffold; placement of the seeded polymer scaffold in a bioreactor and mechanical stimulation by exposure to a pulsatile flux of incremental intensity, thereby forming an extracellular matrix; mounting of the graft on a conduit stabilizer and incubation in cell culture medium; decellularisation of the graft in a washing solution; nuclease treatment of the graft; and rinsing of graft. The invention further comprises and various steps of quality control of the tissue-engineered medical device.

Systems and methods for providing a magnetic fluid (MF) seal suitable for a fluid environment may provide a shaft and a magnet that is cylindrical or ring-shaped. A magnetic fluid may be present between the magnet and shaft. Additionally, pole pieces may also be provided, which are also cylindrical or ring-shaped. These pole pieces are positioned on the shaft so the magnet is sandwiched between the pole pieces. The magnet, pole pieces, and shaft, if magnetic, may attract and retain the magnetic fluid in an annular gap or region between the shaft and the magnet and/or the pole pieces. The magnetic fluid in the annular gap serves as a seal or barrier that prevents fluid from passing through when pressure is below a predetermined level.