A hand-held personal hygiene device includes a main body having an upper end, a lower end, and a pump therein. The pump is configured to pump water or another fluid from an inlet port at the upper end to an outlet port at the lower end. A reservoir has a lower base configured to removably seat in the upper end of the main body to engage and open a self-closing valve with the inlet port of the main body. A tubular nozzle member has a lower end comprising one or more nozzle outlets and an upper end configured to be removably secured to the outlet port of the main body causing liquid pumped by the pump to flow through the tubular nozzle member to the one or more nozzle outlets. The reservoir and the main body may be aligned to form a liquid flow path that may be held vertically to allow gravity flow from the reservoir to the pump.

Provided herein are methods of reducing bioburden of a chromatography resin that include exposing a container including a composition including (i) a chromatography resin and (ii) a liquid including at least on alcohol to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one alcohol are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and a liquid including at least one alcohol, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

The present invention provides a decontamination device capable of accomplishing a decontamination effect with a proper amount of decontamination agent by employing a mist control mechanism and concentrating a mist for decontamination on the surface of an article to be conveyed, and reducing the duration of operations such as aeration to achieve more efficient decontamination works, and a pass box in which the decontamination device is disposed.

The decontamination device of the present invention includes a mist supply means and a mist control mechanism, and the mist supply means converts a chemical for decontamination into a mist for decontamination, and supplies the same to the inside of a working chamber that accommodates the article. The mist control mechanism includes vibration boards disposed adjacent to internal wall surfaces of the working chamber, and the vibration boards are ultrasonically vibrated to generate sound flows from board surfaces by an ultra sound in the vertical direction. The mist for decontamination supplied to the inside of the working chamber is pressed by acoustic radiation pressure to concentrate the mist for decontamination on external surfaces of the article.

A method is used for preparing a product for use in repairing a lesion or defect at a tissue site in a human or animal patient body. The method includes obtaining tissue from a donor human or animal body and freezing the obtained tissue. The method further includes pulverizing the frozen tissue and suspending the pulverized tissue in a fluid. The method further includes homogenizing the tissue suspension and precipitating tissue particles from the homogenized tissue suspension. The method further includes re-suspending the precipitated tissue particles and lyophilizing the tissue re-suspension to provide the product to be used in repairing the lesion or defect.

A multi-chamber package is described including a first and second chamber, the first chamber having a bottom wall and sidewalls defining a cavity, the second chamber having a partially open bottom wall and sidewalls defining a cavity. A first removable seal is positioned over a top surface of the package, fully covering the first chamber and second chamber, and a second seal is positioned over a bottom surface of the partially open floor of the second chamber, fully sealing the second chamber. A method of packaging medical devices is also described.

Systems and methods for performing Direct Sodium Removal (DSR) therapy are provided in which an implantable device includes a pump coupled to an inlet catheter designed for placement in a patient's peritoneal cavity, an outlet catheter designed to be coupled to the patient's bladder, and is operably coupled to an analyte sensor, the pump programmed to transfer and/or cease transfer of fluid from the patient's peritoneal cavity to the patient's bladder for voiding responsive to a level of analyte detected by the analyte sensor. In addition, the system may include a processor that computes an amount of analyte transferred per pumping session.

A device for generating a decontaminating agent vapor, in particular hydrogen peroxide vapor, comprising a single- or multipart evaporator body (1); a heating device for heating the evaporator body (1); at least one supply channel, preferably multiple supply channels, for supplying a liquid decontaminating agent to be evaporated, in particular hydrogen peroxide, to at least one of multiple blind holes (7, 8, 9, 10) arranged in the evaporator body (1); and a flow channel (2) which is arranged above the upper blind holes edges (11, 12, 13, 14) of the blind holes (7, 8, 9, 10) and which connects a carrier medium inlet (3) to an outlet (4) in a gas-conductive manner for a gaseous carrier medium, in particular air, in order to discharge the decontaminating agent vapor through the outlet (4) in a flow direction of the carrier medium. According to the invention, at least two of the blind holes (7, 8, 9, 10), preferably all of the blind holes (7, 8, 9, 10), are fluidically connected together at a distance from the respective upper blind hole edges (11, 12, 13, 14).

A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

A sterilization, disinfection, sanitization, or decontamination system having a chamber defining a region, and a generator for creating a free radical effluent with reactive oxygen, nitrogen, and other species and/or a vaporizer. A closed loop circulating system without a free-radical destroyer is provided for supplying the mixture of free radicals from the generator mixed with the hydrogen peroxide solution in the form of the effluent to the chamber. The system is used in sterilizing, disinfecting, sanitizing, or decontaminating items in the chamber or room and, with a wound chamber, in treating wounds on a body. The wound chamber may be designed to maintain separation from wounds being treated. Various embodiments can control moisture to reduce or avoid unwanted condensation. Some embodiments can be incorporated into an appliance having a closed space, such as a washing machine. Some embodiments may include a residual coating device that deposits a bactericidal coating on sterilized items.

The invention relates to products by processes, product compositions, product formulations and product uses that are all related to reduced ultrapure water cluster sizes in an aqueous composition containing a non-H.sub.2O substance in the reduced size water clusters in order to improve bioavailability of the aqueous composition. The invention processes use higher flow rate of the blended aqueous composition from a jet openings of a nozzle inside the hollow cylinder to reduce sizes of the ultrapure water clusters in the blended aqueous composition of the non-H.sub.2O substance to less than 300 nanometers.