Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.

A system for treating infections in patients that includes an elongate probe configured for insertion into the patient body and a system module coupled with the probe. Sensors are disposed along the probe that detect infectious substances or physiological symptoms of the patient. The probe also includes light disseminating devices configured to expose the infectious substances to a light capable of disrupting the infectious substances, such as light within the ultraviolet spectrum. System logic may activate the light disseminating devices in response to sensor signals. A wireless connection enables clinician interaction with the system via external computing devices. The sensors may be disposed on external surfaces or internal luminal surfaces of the probe. The light disseminating devices may project the light away from the external surfaces or within a lumen of the probe. The light disseminating devices may include optical fibers.

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

A method and a system for producing a change in a medium disposed in an artificial container. The method places inavicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage,

Devices and method are provided for removing toxins, including protein-bound toxins, from blood. The device includes a housing having a receiving space and at least one hollow fiber extending through at least a portion of the receiving space. The at least one hollow fiber is operable to receive the stream of blood. The device further includes a plurality of beads disposed within the receiving space and external to the at least one hollow fiber. The at least one hollow fiber includes a plurality of pores operable to retain the one or more cellular elements of the stream of blood within the hollow fiber and to allow the one or more plasma elements of the stream of blood to pass from the hollow fiber to the receiving space of the housing. Each of the plurality of beads is configured to receive a toxin molecule from the one or more plasma elements.

A fluid processing system including an integrated blood component collection and pathogen inactivation fluid circuit is disclosed.

A driveline for an implantable blood pump including a percutaneous outer tube configured to connect with the blood pump when the blood pump is implanted within a body of a patient and an external controller outside of the body of the patient and at least one ultra-violet light emitter coupled to the outer tube.

A blood processing apparatus including a blood supply unit, a centrifuge, a light irradiation unit, a filtering device, and a blood collection unit, which is characterized in that blood is introduced into the centrifuge and centrifuged, the centrifuged blood is passed through a transparent tube provided in the light irradiation unit while being irradiated with light applied, from the outside of the transparent tube, by a light irradiation device configured to include an infrared lamp with a wavelength of 830?5 nm, a red light-emitting diode (LED) lamp with a wavelength of 635?6 nm, a blue LED lamp with a wavelength of 420?5 nm, a green LED lamp with a wavelength of 530?5 nm, a yellow LED lamp with a wavelength of 585?5 nm, and ultraviolet (UV) lamps, and the blood irradiated with the light is filtered using the filtering device and collected in the blood collection unit.

Disclosed herein are methods and devices for the inactivation of pathogens (e.g., bacteria, viruses, etc.) in ex vivo stored blood products, such as plasma and/or platelets, by means of directing visible light radiation from an illuminating device into blood product storage containers in order to achieve effective pathogen inactivation without the presence of an added photosensitising agent in the blood product. An exemplary apparatus includes a control unit that operates a light source that emits light in the wavelength region of about 380-500 nm which is directed onto blood product storage bags at sufficient intensity to penetrate the bag material and the opaque blood product therein in order to inactivate pathogens in the blood product but at dose levels that cause no significant detrimental effects on the blood product.