Described herein is a method of forming individual tubes or sachets containing fluent material, and a packaging machine for doing so, are described. The side of the foil which will be in contact with the fluent material when the package is formed is exposed to plasma in mist or aerosol form as the tube or sachet is formed from a strip of laminate material (1), which is folded about a former (2) into a closed tube or sachet which passes over the open end of a dispensing tube (3) from which the fluent material is dispensed. A mist of plasma is injected into the interior of the material tube as it is formed, extracted from the area once it has passed over the interior walls of the laminate tube.

A system for sterilizing a drug delivery device includes a drug delivery device having a first self-healing seal configured to seal a fluid reservoir disposed within the drug delivery device. A sealable container is configured to receive the drug delivery device therein. The sealable container has a base portion and a cover portion. The cover portion has a second self-healing seal positioned to align with the first self-healing seal when the drug delivery device is disposed within the sealable container. A fill port includes a fill path, the fill path being configured to pass through the first and second self-healing seals to fluidly couple the fill port to the reservoir of the drug delivery device. Other systems, methods, and devices of sterilization are also disclosed.

Methods and systems are provided for calibrating a UV lamp having a plurality of arrays or channels of light emitting diodes. The calibration involves adjusting a drive current applied to the UV lamp based on an actual irradiance output by its light-emitting diodes relative to a target irradiance. The calibration is selectively performed when a stabilized temperature condition of the lamp is met.

A system for irradiating a microplate may include a light engine with a plurality of light sources, such as light-emitting diodes, included in one or more linear arrays. The plurality of light sources are configured to emit germicidal irradiation, which is directed to the microplate by optical components, such as optical lenses positioned on top of each well of the microplate. The linear array is linearly movable so that as the linear array scans across the microplate, the optical components direct the germicidal irradiation to a plurality of surfaces of each well.

Disclosed herein is a device in the form of a bung for insulating a container interior from the ambient environment, the bung comprising: a plurality of insulating segments; and one or more barriers for reflecting infrared radiation. Disclosed is: a method of preparing a shipping system for retaining a cryopreserved sample, the method comprising: loading a cryopreserved sample into a container such as a vacuum flask; and fitting the bung to the container to insulate the container interior from the ambient environment, and a method of cooling a container, such as a vacuum flask, for retaining cryopreserved samples to a desired temperature, the method comprising: cooling the container interior by pouring a cryogenic fluid such as liquid nitrogen into the container; and emptying the cryogenic fluid from the container, once the cooling has at least partially taken place.

A method for validating a method for sterilizing an item, making it possible to validate the sterility assurance level achieved with this sterilization method. The method includes carrying out a first step of contaminating a container receiving the item with more than 10.sup.5 living microorganism cells, then carrying out a first sterilization cycle with the chosen method, then opening the container in order to contaminate it again with more than 10.sup.5 living microorganism cells, then carrying out a second sterilization cycle with the same method, and finally checking the sterility of the container after the first sterilization cycle and after the second sterilization cycle. The method is applicable in particular for products and devices intended for health use.

Even when the filling speed increases, the surface temperature of a molded bottle falls within a constant range, and a sterilizer adequately sterilizes the bottle.

A preform is heated, the heated preform is sealed in a mold, the preform sealed in the mold is blow-molded into a bottle, the surface temperatures of a neck portion, a body portion, and a bottom portion of the molded bottle are measured, and the mold temperatures of a neck portion, a body portion, and a bottom portion of the mold is so adjusted that the measured surface temperature of the bottle falls within a specified temperature range.

Sterilizing packaging units including packing a sterilization container by receiving a rigid body having a lower surface, an upper rim, and side walls between the lower surface and the upper rim, wherein the upper rim defines an opening to an interior space of the body, arranging one or more packaging units in the interior space of the body, covering and sealing the opening of the body with a lid, and engaging a valve body in fluid communication with the interior space of the body to move the valve body to an open position; exposing the interior space of the body and the packaging units to a sterilant until the packaging units are sterilized; subjecting the interior space of the body to a negative pressure differential; and engaging the valve body to move the valve body to a closed position that seals the interior space of the body.

A method of pairing bioabsorbable staples in a staple cartridge with the tissue being treated such that the staples are structurally sufficient during the healing window of the tissue but completely bioabsorb shortly thereafter.

A disinfectant device provides a solution to disinfect bulk quantities of small items such as food items. The disinfectant device has a housing, an inlet, an outlet, a shaker tray positioned to descend from a first height on the inlet side to a second height on the outlet side, the second height lower than the first height, wherein the shaker tray is configured to shake or vibrate via a motor, and at least one disinfecting light is positioned within the housing and above the shaker tray, the light configured to disinfect items passing on the shaker tray. The disinfectant device may have a hopper having a gate to the shaker tray. The gate may be manually operated or actuated by a motor to control the number of items on the shaker tray at any given time, thereby ensuring adequate exposure to the disinfecting light.