A contactless wound treatment barrier assembly carrying a primed wound treatment composition carrier is secured to a patient's skin at a location encapsulating a wound. A wound treatment composition is emitted from the carrier in a gaseous state. The gaseous emission remains within an interior volume of the wound treatment barrier assembly. The design of the wound treatment barrier assembly can minimize any contact between a body of the wound treatment barrier assembly, the wound treatment composition carrier and the wound. An insole carrying a wound treatment composition (such as elemental Iodine) can be used in any of a variety of forms. The insole would deliver the treatment composition. The insole can be designed to provide contactless or contact delivery of the treatment composition.

The disclosure relates to an antimicrobial hemostatic device having a substrate configured to be in contact with a bleed, where the substrate includes a hemostatic agent, a biguanide based antimicrobial agent, or a pharmaceutically acceptable salt thereof, and a binder configured to maintain the hemostatic agent with the substrate. The disclosure further includes methods of making and using such devices.

Disclosed are a fibrinogen solution and a thrombin solution. The fibrinogen solution comprises fibrinogen at a concentration of at least 40 mg/ml, factor XIII, pharmaceutically acceptable additives and water. The dynamic viscosity of the fibrinogen solution measured at 20 C. increases at most by 35% after storing the solution at 20 C. for 30 days. The thrombin solution comprises thrombin, pharmaceutically acceptable additives and water. The thrombin activity decreases at most by 15% after storing the solution at 25 C. for 14 days. Also disclosed is a fibrin sealant kit with a first container comprising the fibrinogen solution and a second container comprising the thrombin solution. Further, methods for preparing a fibrin sealant and methods for treating a wound are disclosed.

The present invention concerns antimicrobial multi-layer wound dressings having an antimicrobial agent located at one or more interfaces between opposing surfaces of the layers of the wound dressing. This improves the migration of antimicrobial agent and allows the dressing to provide a higher overall concentration of antimicrobial agent throughout the dressing. This will assist clinicians when treating wounds by reducing the microbial load at the wound bed thereby reducing the risk of wound infection.

The present disclosure relates generally to materials and medical devices impregnated with antimicrobial compounds. More specifically, the materials are medical matrix materials comprising nanopores or nanochannels in which the antimicrobial compounds are disposed. In other embodiments, medical matrix materials comprises nanomaterials and antimicrobials distributed throughout the material. The materials described herein are useful for a broad spectrum of medical devices and consumer products. The present disclosure further provides methods of making the antimicrobial materials and medical devices disclosed herein.

Disclosed are a fibrinogen solution and a thrombin solution. The fibrinogen solution comprises fibrinogen at a concentration of at least 40 mg/ml, factor XIII, pharmaceutically acceptable additives and water. The dynamic viscosity of the fibrinogen solution measured at 20 C. increases at most by 35% after storing the solution at 20 C. for 30 days. The thrombin solution comprises thrombin, pharmaceutically acceptable additives and water.

Disclosed embodiments relate to wound care materials and methods that comprise a self-gelling composition, configured to form a gel upon contacting fluid. The self-gelling composition is a substantially homogeneous mixture, and comprises fluid-absorbent particles loaded with iodine-based antimicrobial agent, a dehydrated hydrogel powder, and a polymer base, configured to allow dispensing the self-gelling composition from a syringe or tube and to prevent the self-gelling composition from gelling prior to contacting fluid. The gel performs one or more of the following tasks during a wear time, when applied at the wound: absorbing fluid or exudate, releasing iodine-based antimicrobial agent, achieving antimicrobial activities at the wound, remaining structurally integral and cohesive, protecting the wound from exposure to microorganisms, and facilitating healing. After a wear time of at least three days, the gel can be removed in two pieces or less and leave less than 5% residue by weight.