A bacterial adsorption dressing in contact with a wound and a method of manufacturing the bacterial adsorption dressing are provided. A bacterial adsorption dressing with a nonphotocatalyst includes a fabric layer including a polyester fiber as a supporter, and a nonphotocatalyst coating layer formed on the fabric layer and including titanium dioxide phosphate.

To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 90% or less is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film. If necessary, a metal oxide layer made of a metal oxide having an isoelectric point of less than 7 is formed on the bioimplant thereby suppressing adhesion of bacteria.

Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

The present invention relates to a mineralized collagen material, a preparation method therefor, and an application thereof. The preparation method comprises: dissolving type I collagen, a calcium source, and acid in a first solvent to obtain a first solution; dissolving alkali and a phosphorus source in a second solvent to obtain a second solution; under the condition that a temperature is less than or equal to 45 C., adding the second solution into the first solution and mixing to obtain a third solution; and placing the third solution in a deionized water solvent or an ethanol solvent for soaking, and removing impurities to obtain a mineralized collagen gel. The method has the advantages that: by introducing glycerol into a reaction system, the assembly speed and an assembly structure of the collagen can be controlled, and the nucleation and crystallization speed of a mineral substance and a structure thereof can be controlled, so that the collagen can be assembled into a large-size space network structure at a controllable speed, and mineralization is deeply performed at the same time, so as to prepare continuous large-size mineralized collagen blocks; and high mineralization of the collagen is implemented in a very small reaction system, and the collagen gel can be prepared without repeated replacement of a mineralizing solution, a macromolecular additive, and extra cross-linking.

A flexible anchor for coupling a suture to a bone is provided. The anchor is composed of non-woven electrospun fibers and has an elongate tubular body that extends from a first end to a second end. The anchor is configured to receive a suture that enters the anchor through a first aperture and exits the anchor through a second aperture. When free ends of the suture are pulled, the anchor transitions from a first configuration to a second anchoring configuration.

Materials and methods for preventing and treating anastomotic leaks are disclosed. Data establishes that pathogenic microbes interfere with establishing epithelial cell barriers in anastomoses and, more generally, with the reconnection of any two portions of like or different tissues comprising epithelia. Suitable prophylactic and therapeutic composition comprise, e.g., a phosphorylated high molecular weight polyethylene glycol compound.

A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.

Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients.

The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties.

The present invention relates to the use of polyphosphate in crystalline form for treatment of wounds, especially bleeding wounds, wherein the anion of the polyphosphate has a (numerical) average of at least 4 phosphorus atoms per polyphosphate anion. The invention additionally relates to a composition suitable for treatment of wounds, especially bleeding wounds, comprising an inventive polyphosphate and a carrier material. The invention further provides a method suitable for production of the inventive composition, which comprises the introduction of the polyphosphate and optionally further haemostatic agents into the carrier material, or into a component or into a precursor of the carrier material.