Described herein are substrates, devices, methods for treating and preventing bacterial and fungal infections, such as infections associated with medical devices, and the like. Materials, substrates and devices of the present disclosure include materials, such as medical grade polymers, having a coating/layer of polyene antimycotic molecules coupled to a surface of the polymer substrate. In certain aspects, substrates and devices of the present disclosure also include a nitric oxide (NO) releasing material also embedded in/coated on the material. Methods of the present disclosure includes methods of making the compositions and/or devices of the present disclosure including materials functionalized with polyene antimycotic molecules and NO releasing materials. Embodiments also include methods of using the materials, substrates, and devices of the present disclosure to treat/prevent fungal and/or bacterial infections in a subject, particularly infections associated with the use of a medical device.

Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.

A multi-layered wound care product includes an upper liquid-absorbing layer, an intermediate occlusive layer; and an active agent-releasing bottom layer. The latter two layers have common pores or perforations that enable the passage of wound exudate through the two layers to reach the liquid-absorbing layer. A use of the multi-layered wound care product for treatment of acute and chronic wounds and a method of producing the multi-layered wound care product are also provided.

Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.

Described herein are compositions comprising a nitric oxide releasing material comprising a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network; and (b) a silicone oil. Also described herein are articles composed of the compositions described herein and methods for using the same. The compositions described herein provide highly sustained, long-term nitric oxide release that have numerous biological activities such as, for example, preventing localized platelet activation, fibrinogen adhesion, and biofilm formation for a prolonged period of time.

Described are coatings for medical devices and methods of forming same.

A multi-layered wound care product includes an upper liquid-absorbing layer, an intermediate occlusive layer; and an active agent-releasing bottom layer. The latter two layers have common pores or perforations that enable the passage of wound exudate through the two layers to reach the liquid-absorbing layer. A use of the multi-layered wound care product for treatment of acute and chronic wounds and a method of producing the multi-layered wound care product are also provided.

A composition comprising an organic photoactivator, a gasotransmitter salt which converts into a gasotransmitter via electron transfer, and an electron donor which donates an electron to the photoactivator when the photoactivator is in a photo-excited state.

A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37 C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.

A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.