The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.

Provided are the use of poly(N-isopropylacrylamide-co-butyl methacrylate) in preparing an embolism material for blood vessels, an embolism material for blood vessels and the use thereof in preparation of drugs. The embolism material for blood vessels comprises poly(N-isopropylacrylamide-co-butyl methacrylate) and a dispersion medium consisting of an electrolyte, a contrast agent, a pH regulator and water. The concentrations of the polymer, electrolyte and contrast agent are respectively 5-30 mg/ml, 0.1-30 mg/ml and 100-350 mg/ml based on iodine. The embolism material for blood vessels is suitable for embolization therapy of tumors in hypervascular and parenchymal visceral organs.

The present disclosure provides antimicrobial coating compositions that are used to form residual antimicrobial coatings on medical implements and medical devices including the components of medical equipment such as CPAP/BiPAP machines. Antimicrobial coating compositions comprise at least one of an organosilane (R.sup.1O).sub.3Si—R.sup.2—Z, an organic amine R.sup.9R.sup.10R.sup.11N, a titanium (IV) species, a 1,2-diol, an α-hydroxy acid, a β-hydroxy acid, and an organosilane grafted parylene polymer, wherein R.sup.1 is H, alkyl, substituted alkyl, aryl or substituted aryl, R.sup.2 is a bivalent linker, Z is a nucleophile, leaving group, or quaternary nitrogen substituent, and R.sup.9, R.sup.10 and R.sup.11 are independently H, alkyl, substituted alkyl, aryl, substituted aryl or cyclic.

The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.

Antitoxic fibers and fabrics contain impregnated material including an antitoxin. A method for producing antitoxic fabric and products includes impregnating a fabric formed from nonpolymeric or polymeric fibers by fully immersing the fabric in a solution of a concentrate of triiodide and an additive portion that includes an oil of ethoxylated fatty acids in sufficient proportion to stabilize the triiodide in the fabric. An antitoxic fabric includes polymeric or nonpolymeric fibers and impregnated material, which includes an antitoxin, the antitoxin being triiodide, and additional chemical components including an oil of ethoxylated fatty acids in sufficient proportion to stabilize the triiodide in the antitoxic fabric. The antitoxic fabric is efficacious on contact, and maintains efficacy with negligible toxicity in use. Products with antitoxic fabric include wound dressings, gowns, surgical drapes, protective clothing, shoe covers, gloves, hair covers, air filters, including facemasks, privacy, hygienic products, curtains, medical tape, and wipes.

The invention relates to hardenable ceramic bone substitute compositions having improved setting, powders for such compositions and methods for their manufacture and use in medical treatment. More specifically the invention relates to hardenable bone substitute powder and hardenable bone substitute paste with improved setting properties, comprising calcium sulfate and heat-treated hydroxyapatite (passivated HA), which bone substitute is suitable for treatment of disorders of supportive tissue such as bone loss, bone fracture, bone trauma and osteomyelitis.

The present disclosure is directed to systems, method of manufacture, and packaging configurations for an antimicrobial orthopedic implant having an antimicrobial coating on the outer surface of the implant including a vaporizable antimicrobial agent in a surface area concentration on the outer surface sufficient to prevent bacterial growth on the orthopedic implant, and can additionally provide a clinically effective zone of inhibition around the orthopedic implant. In certain embodiments, a container, a reservoir of the vaporizable antimicrobial agent, and the orthopedic implant are configured to remain thermally stable in a temperature range up to 200C.

Antitoxic fibers and fibrous media contain impregnated material including an antitoxin. A method for producing antitoxic fibers and fibrous media includes impregnating a fibrous media by dipping in a dipping solution containing a concentrate of an antitoxin to form a fiber with impregnated material including an antitoxin. The impregnated material is at least about 1.0% to about 2.5% by weight of the fibers and includes additive chemical components including at least one of an anionic, cationic or nonionic component, an oil and/or an organic solvent, and an alcohol. The additives include those found in a spin finish. The antitoxin is in an amount of at least 0.1% by weight of the fiber. The manufacturing process can be applied to any woven or nonwoven media. Products with antitoxic properties formed therefrom include wound dressings, gowns, articles of clothing, surgical drapes, protective clothing, shoe covers, gloves, hair covers, air filters, including facemasks, privacy, hygienic products, curtains, medical tape, and wipes.

An absorbable, biocompatible barbed microcatheter for delivering therapeutic fluids to a patient includes a hollow tube having an elongated lumen that extends between proximal and distal ends of the hollow tube, a plurality of barbs projecting from the hollow tube, and a plurality of fluid egress openings formed in the hollow tube that are in fluid communication with the elongated lumen. The fluid egress openings are evenly spaced from one another along the length of the hollow tube. An anchor is secured to the proximal end of the hollow tube, and a surgical needle is secured to the distal end of the hollow tube. Two or more of the fluid egress openings formed in the hollow tube have different sizes so that a first fluid egress opening located adjacent the anchor is larger than a second fluid egress opening adjacent the surgical needle.

Disclosed herein is a biomaterial for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. The biomaterial can comprise a plurality of geometric elements and a therapeutic agent. The biomaterial can comprise a first geometric element formed by a porous border that comprises a polymer and the therapeutic agent. The biomaterial can comprise a second geometric element formed by a non-porous border and a solid region, wherein the therapeutic agent may not diffuse into the second geometric element. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.