Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Disclosed herein is a wetted medical device, methods for preparing wetted medical devices, and kits to make the same. The disclosed wetted medical device includes a self-healing layer of lubricating fluid on a surface of the medical device. The surface includes a polymer layer having a roughened texture, which interacts with and attracts the lubricating fluid to form a lubricating fluid layer.

Provided are the use of poly(N-isopropylacrylamide-co-butyl methacrylate) in preparing an embolism material for blood vessels, an embolism material for blood vessels and the use thereof in preparation of drugs. The embolism material for blood vessels comprises poly(N-isopropylacrylamide-co-butyl methacrylate) and a dispersion medium consisting of an electrolyte, a contrast agent, a pH regulator and water. The concentrations of the polymer, electrolyte and contrast agent are respectively 5-30 mg/ml, 0.1-30 mg/ml and 100-350 mg/ml based on iodine. The embolism material for blood vessels is suitable for embolization therapy of tumors in hypervascular and parenchymal visceral organs.

Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.

The disclosure pertains to radiopaque, unsaturated multi-arm polymers that comprise a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage. In some embodiments, the disclosure pertains to systems for forming hydrogels, which systems comprise (a) a polyamino compound and (b) a radiopaque, unsaturated multi-arm polymer that comprises a plurality of hydrophilic polymer arms having end moieties comprising one or more radiopaque halogen groups and one or more unsaturated groups, the end moieties linked to the hydrophilic polymer arms though an ester or an amide linkage, wherein the one or more unsaturated groups are reactive with the amino groups of the polyamino compound. Other embodiments pertain to methods of treatment using such systems and to hydrogels formed from such systems.

The invention relates to hardenable ceramic bone substitute compositions having improved setting, powders for such compositions and methods for their manufacture and use in medical treatment. More specifically the invention relates to hardenable bone substitute powder and hardenable bone substitute paste with improved setting properties, comprising calcium sulfate and heat-treated hydroxyapatite (passivated HA), which bone substitute is suitable for treatment of disorders of supportive tissue such as bone loss, bone fracture, bone trauma and osteomyelitis.

There is provided an absorbent system for wound care products having a liquid-absorbing, wound-contacting, lower layer and a more highly absorbent upper layer in liquid communication with said lower layer. Liquid communication may be provided by pores running between the layers. The dressing may include antimicrobial agents, agents to promote healing and other functional agents.

The invention relates to process for creating catheters that are coated with these layers of elastomeric polymeric coating with an antitoxic agent, antimicrobial resin, affixed to the surface of said polymeric coating. The method of coating an elastomeric material on the exterior and/or the interior includes: (a) providing a base elastomer comprised of an elastomeric polymer; (b) dipping the elastomer in a second organic solution containing a polymer to form a secondary coating over the barrier coating; (d) coating the elastomer with suspension containing polyiodinated resin particulate in an organic solvent to anchor the particulates to the secondary coating; and (e) drying the elastomer.

An identification device that combines an antimicrobial coating with a printable substrate. For example, the invention includes a wristband with a face stock supporting indicia which are applied on (such as through thermal transfer printing) or through (such as through direct thermal printing) an antimicrobial layer. The antimicrobial layer is preferably a coating or varnish that is applied as the outermost layer and can bind with thermal transfer printing ink or supports pass through of direct thermal printing on a chemically receptive sublayer. The antimicrobial varnish includes varnish compounds and antimicrobial compounds such as a silver zeolite ion that is configured to react to moisture with a controlled release of microbial disinfectant. Preferably, the wristband is a hospital wristband bearing on-site printed identification indicia for a patient.

Therapeutic compositions, primarily for topical application, and methods of making and using the composition. Pharmaceutical compositions formulated for specific forms of administration are also provided.