Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material. Methods of perivascular antiproliferative drug administration also are disclosed.

Provided is an antimicrobial dressing, which includes: a first cover member having a plurality of pores formed therein and contacting a wound; an antimicrobial membrane that is made by accumulating nanofibers containing a water-soluble polymer that is dissolved in an exudate secreted from the wound, a synthetic polymer, and an antimicrobial substance released due to dissolution of the water-soluble polymer, the antimicrobial membrane being laminated on the first cover member and having a plurality of pores formed therein; and a second cover member laminated on the antimicrobial membrane and having a plurality of pores formed therein and exposed to an external air.

A surgical system including an implantable medical device having a size and shape. The surgical device having a substrate and a coating that covers at least a portion of the substrate. The coating including collagen, glycerin and a hemostatic agent. The substrate including a first piece and a second piece that is joined with the first piece. The first piece and the second piece forming a pocket having a cavity and an opening that is in communication with the cavity. The device being pre-formed such that a size and shape of the cavity conforms to the size and shape of the implantable medical device.

The present invention addresses the problem of providing a means for treating pain in the hands or feet, which can be performed in a safer manner and works by embolizing abnormal capillary vessels. The present invention provides a treatment agent for pain in the hands or feet, wherein: the pain treatment agent contains a particulate embolic material having an average particle size of 10 to 200 ?m; the pain treatment agent is employed by being injected into an artery in a hand or a foot; and the administration of the pain treatment agent is completed on the basis of confirmation of at least one predetermined phenomenon.

A method for implanting a drug delivery device by a laparoscopic procedure may include inserting the drug delivery device through a proximal end of a trocar, moving the drug delivery device through the trocar to an implantation site at a distal end of the trocar. The drug delivery device is then positioned at the implantation site using a manipulator through the trocar.

A conical shaped venous valve structure with a plurality of fluid flow modulating means that open and allow antegrade blood to be transmitted out of the valve structure and into and through an associated cardiovascular vessel when the valve structure is disposed in the cardiovascular vessel and the antegrade blood exhibits a positive pressure relative to the exterior pressure.

Use of 10H-benzo[g]pteridine-2,4-dione derivatives as photosensitizers in the inactivation of microorganisms.

The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.

The disclosure provides hyaluronic acid (HA) gel formulations and methods for treating the appearance of the skin. The formulations contain hyaluronic acid and at least one additional ingredient. Methods for treating lines, wrinkles, fibroblast depletions, and scars with the disclosed composition are provided as well.