The invention relates to a method for assembling a clay-nanoparticle gel suitable for loading with one or more molecule species such that they are spatially structured therein, and a method for forming a clay-nanoparticle gel comprising one or more spatially structured molecule species. The invention further relates to structured clay nanoparticle gel and their use, for example in treatment.

Embodiments of the present disclosure provide a drainage apparatuses with scar gradient control capabilities for degradable glaucoma and methods of making the same cross-reference to related applications, comprising a long-strip-shaped drainage sheet with a uniform overall cross-sectional size, wherein the drainage sheet is made of a biodegradable material, an outer surface of the drainage sheet is provided with a drainage gap that penetrates through opposite sides of the drainage sheet, an outer surface of the drainage sheet is coated with a biodegradable surface coating, and the surface coating carries an anti-scarring drug, wherein the anti-scarring drug is configured to be gradually released as the surface coating degrades, and a distribution concentration of the anti-scarring drug within the surface coating varies in a non-monotonic manner.

A sanitary article, such as a sanitary pad, a pantyliner, a pant diaper or an open diaper, according to the present disclosure includes a fluid permeable topsheet and a backsheet. The sanitary article extends in a longitudinal direction and a transverse direction and has first and second longitudinal side edges and a front and a rear edge. The topsheet is provided with a dry coating in a coated zone on a first side thereof, the first side of the topsheet being the wearer facing side of the topsheet, the dry coating is a water-soluble dry coating comprising allantoin and betaine.

The present invention relates to a method for dynamic filtration of a cross-linked biopolymer-based hydrogel to remove unwanted molecules from the gel. In particular, the invention relates to dynamic filtration of a hyaluronic acid hydrogel using a dynamic filtration construction with rotating and semipermeable filter discs.

It is provided a composition comprising phytic acid or a pharmaceutically acceptable salt thereof, for use in reducing or preventing microorganisms' proliferation and/or encrustations caused by a urinary tract device implanted in a subject, thereby preventing or treating clinical complications related to microorganisms' proliferation and/or encrustations. The composition can further comprise a urine acidifier such as methionine, a crystallization inhibitor such as theobromine and/or other agents.

A Delivery System for delivery of an Active Component is provided. The Delivery System comprises a Delivery Matrix and an Active Component. The Delivery Matrix has one or both of (i) a Cationic Component; and (ii) a Matrix Forming Substance. The Cationic Component has one or both of: (i) a cationic polymer or cationic copolymer, and (ii) a positively charged non-polymeric compound or composition. The Active Component comprises a cationic bioactive. The Delivery Matrix has a mEq amount of positive charge which is equal to or exceeds the mEq amount of positive charge of the Active Component. The Delivery Matrix may comprise chitosan, or other biopolymers, synthetic polymers, matrix polymers and large molecules, which themselves are matrix forming, or are combined with a Matrix Forming Substance and one or more other Cationic Components to form the positively charged Delivery Matrix.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

Disclosed are methods of treating peripheral artery disease (particularly chronic limb threatening ischemia (CLTI)) with implantation of a polymeric scaffold into a vessel located below the knee. After implantation into a blood vessel of the patient below the knee, efficacy of the procedure is measured by performing duplex ultrasound (DUS) and/or angiography to measure binary restenosis at the site of the target lesion, where binary restenosis is defined as the presence of a hemodynamically significant restenosis of >50% identified through angiography, or peak systolic velocity ratio (PSVR) 2.0 as identified by DUS. The scaffold is made from a bioresorbable polymer. The scaffold has a pattern of interconnected elements. The interconnected elements include a plurality of rings connected by links, wherein each ring includes struts and crowns, and the struts are configured to fold at the crowns when the scaffold is crimped to a balloon.