[Summary]

The present invention has a special filling (WIE) property parameter value developed using microrheology technology, and thus exhibits improved high viscoelasticity flow properties, has low mobility when injected into skin whilst still maintaining the shape thereof, and thus has excellent soft tissue restoration properties, for example for the cheeks, breasts, nose, lips or bottom, and excellent volume expansion and wrinkle alleviation properties.

A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.

The present disclosure provides fibrous composition comprising a soluble or a dispersible N-halamine, for example 1-chloro-2,2,5,5-tetramethyl-4-imidazolidinone (i.e., compound I). Additionally, the disclosure provides methods for producing the fibrous compositions comprising a soluble or a dispersible N-halamine as well as methods for protecting a person from an infection using the fibrous compositions comprising a soluble or a dispersible N-halamine. The compositions and methods according to the present disclosure provide several advantages, such as stability, less time to provide sufficient antimicrobial inactivation, and are inexpensive and require lower amount of active concentrations to be effective.

A method for inhibiting biofilm formation by bacteria on a surface or disrupting existing biofilm on a surface, comprising contacting said surface or existing biofilm with at least one compound selected from the group consisting of 2-(indolin-2-yl)-1H-ind, di(1H-indol-3-yl)methane and 1,1′-biindole, is provided.

The present invention relates to a process for preparing a hydrogel, comprising the following steps: a) provision of a polysaccharide or a salt thereof; b) crosslinking of the polysaccharide in the presence of 0.05 to 10 mol %, preferentially 0.1 to 2 mol %, of at least one crosslinking agent, or a salt thereof, per 1 mol of repeat units of the polysaccharide; c) functionalisation of the polysaccharide with at least one silylated molecule of formula Chem. I or a salt thereof; d) sol-gel reaction of at least one part of the Si—OR.sup.10 groups and optionally at least one part of the SiOR.sup.4 groups of the molecule of formula Chem. I or a salt thereof when they are present.

Provided are injectable, hyaluronic acid-based hydrogel compositions including conjugated vitamins.

Stable formulations for a dimeric naphthalimide coating and preparation methods for forming said coating, dimeric naphthalimide coated articles, as well as sterilization and storage-stable packaging thereof.

The present invention relates to a silk fibroin composite material that overcomes the limitations of two physical properties, which were conventional trade-offs, by exhibiting excellent toughness and excellent ductility. Specifically, by preparing modified silk fibroin using a urethane oligomer as a casting substrate, a silk fibroin composite material exhibiting excellent toughness, tensile stress, and elastic modulus may be prepared.

The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.

Disclosed herein are nitric oxide donors and methods of use thereof.