Implantable medical product, comprising a basic body and an imidazole derivative in the form of its free base; wherein said basic body has on its polymeric surface a layer containing the imidazole derivative as an active ingredient, which displays an antithrombogenic, antiproliferative, anti-inflammatory or antiadhesive effect, or a combination thereof.

Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes using intra-articular administration.

An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.

The invention concerns an implant material for filling bone defects, bone regeneration and bone tissue engineering, an implant comprising this material, a method for manufacturing such an implant material.

The implant material of the invention comprises a hybrid material doped with an osteoinductive nutrient N comprising: a bioactive glass M made from SiO.sub.2 and CaO, optionally containing P.sub.2O.sub.5 and/or optionally doped with strontium, and a biodegradable polymer P, this hybrid material being doped with an osteoinductive nutrient N.

The invention is applicable, in particular, in the medical field.

Methods, copolymer materials and devices are provided for embolic arterial interventions (embolization therapy or embolotherapy). More particularly, radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapies, comprising copolymers of iodine-containing, halogenated phenyl-containing units, such as iodinated desaminotyrosine derivatives, and rubbery components, such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC), are provided. The provided microbeads may further contain, or be coated with, therapeutic agents such as paclitaxel, for targeted delivery of the therapeutics.

A medical device substrate with a coating including a functional layer located on the substrate, with the functional layer including at least one sugar alcohol and being bonded to the substrate directly or indirectly via a functionalization of the sugar alcohol. Alternatively, the functional layer may also include other saccharides, in which case it is essential that polymerization of the saccharides takes place only upon bonding to the substrate. The inventive medical device exhibits reduced platelet adhesion and aggregation.

The present invention relates to a compression bandage for treating wounds comprised of a linear elastic compression wrap and a sterilized polymer foam layer containing a plurality of antimicrobial dyes with at least one dye being gram positive and at least one other dye being gram negative and a biofilm reduction agent and wherein said foam is secured to said linear elastic compression wrap.

The present invention relates to an implantable cell chamber device capable of retaining cells but permitting diffusion of biomolecules. Also disclosed are methods for delivering a therapeutic biomolecule to a subject in need thereof on a continuous or semi-continuous basis, by administering to the subject a cell chamber device comprising cells that secrete the therapeutic biomolecule.

In order to provide medical devices having a coating for local prophylaxis and treatment of undesirable cell proliferation and vasoconstriction, a medical device comprising a coating on at least a portion of the surface is proposed, said coating comprising at least one limus substance in non-encapsulated crystalline form, wherein the at least one non-encapsulated limus substance is applied directly from a solvent mixture of at least one organic solvent and water. The formation of crystals of the limus substance can be brought about or enhanced by slowing down the evaporation of the solvent mixture.

In addition, a method for preparing the medical devices is proposed.

A method of generating monodispersed and homogenous microspheres comprising sirolimus is disclosed. The method can include producing sirolimus droplets using microfluidic step emulsification. The sirolimus droplets can include a drug loading wt % that is less than about 50% or about 100%. The method can further include washing the droplets to remove poly (vinyl alcohol). The method can also include removing solvent from the sirolimus droplets.