A wound management system can comprise a surgically acceptable adhesive disposed over a wound and a surgically acceptable film repositionably disposed over the surgically acceptable adhesive, and methods of managing a wound involving the same.

In an embodiment, a stent (S) implantable in a vessel of a patient, comprises recesses (200) loaded with an active principle with anti-inflammatory activity (10) and an active principle with anti-proliferative activity (20). The active principle with anti-inflammatory activity (10) and the active principle with anti-proliferative activity (20) have respective formulations, whereby the active principle with anti-inflammatory activity (10)and the active principle with anti-proliferative activity (20) have respective release kinetics as a function of said formulations, with the release of the active principle with anti-inflammatory activity (10) being faster than the release of the active principle with anti-proliferative activity (20).

The present disclosure relates to methods and compositions for suppressing pathogenic bacterial growth, fungal growth, or microbial growth in or on a selected area of skin or open wound. An area of the skin or open wound having pathogenic bacterial growth, fungal growth, or microbial growth is selected for the suppression of the growth. A suppressing material comprising punicic acid is applied to the selected area of the skin and the pathogenic bacterial growth, fungal growth, or microbial growth is suppressed. Methods of making and using the suppressing material comprising punicic acid are also presently provided.

Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.

This invention provides compositions and methods for cellular regeneration and more rapid healing of surface lesions such as cuts, abrasions, rashes and other skin disturbances. A preferred consumer-based and battlefield embodiment features a spray-on composition delivering at least one substance that stimulates intercellular communication using tunneling nanotubes (TNTs). The induced TNTs increase transport of chemical and/or electrochemical information between more stable and nascent cells or between more intact and damaged cells. The inventive substance is applicable for use for ordinary household type injuries as well as industrial and/or battlefield events, perhaps from physical or chemical accidents or even several types of chemical weapons. Another preferred embodiment incorporates a sealant composition or coating to shield the affected surface area designated for healing from contamination and further damage, e.g., microbial, contact pressure, solar and other sources of radiation, etc.

Methods for functionalizing the surface of nanofiber substrates, including electrospun fibers and non-woven or woven mats of fibers are described. Functionalized nanofiber substrates presenting biologically active moieties such as biotin and saccharides are described.

A wound management system can comprise a surgically acceptable adhesive disposed over a wound and a surgically acceptable film repositionably disposed over the surgically acceptable adhesive, and methods of managing a wound involving the same.

Disclosed are compositions, materials, garments, devices, and methods for controlling or neutralizing offensive odors associated with mammalian urine. For example, disclosed are personal care products (e.g., diapers), deodorizing colloidal compositions, urine-based fertilizers, portable urination systems, and methods of their use. Such deodorizing colloidal compositions, urine-based fertilizers, portable urination systems are characterized in that they contain an acrylate polymer comprising at least one acrylic acid monomer or salt thereof, which imparts an odor-neutralizing effect. Also provided are methods of recovering water from the systems disclosed herein.

The present disclosure provides click-crosslinked hydrogels and methods of use.

Methods for applying a sphingolipid aggregate coating to a surface of a substrate for inhibition and prevention of biofilm growth, methods for inhibiting and preventing biofilms, biofilm-inhibiting coatings and coated devices are provided. Coating processes include suspending an amount of sphingolipid in a medium-to-fast-evaporating organic solvent; b) applying energy to the suspension sufficient to create a colloidal dispersion of sphingolipid in the solvent; c) heating the dispersion sufficient to create a solution; and d) coating the surface of the substrate with at least one application of solution, each application followed directly by a complete solvent evaporation period. The resulting coatings exhibit aggregate architectures particularly effective for inhibition and prevention of biofilms.