The present invention provides a biocompatible hydrogel composition comprising glycolipids and silk fibroin (SF) wherein glycolipid is preferably sophorolipids (SL). The said composition is useful in preparation of 3D scaffold for use in tissue engineering, and in the biomedical field. The present invention also provides a process for preparing such a composition and a process for acceleration of gelation time of silk fibroin (SF) in the presence of sophorolipid.

A hot melt wetness indicator comprising an adhesive base composition utilizing a halogen-free species, namely nitrazine yellow, to trigger color change in hygiene articles, such as disposable diapers, to serve as moisture or wetness indicator upon insult. In some embodiments of the invention, the wetness indicator turns from yellow to purple.

The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.

An in-vivo implantable prosthesis coated with crosslinked polyphosphoryicholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group according to the present invention, and then irradiating UV rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.

The present invention provides a biological fiber membrane formed by bacteria of the genus Gluconacetobacter. The biological fiber membrane includes a first surface layer and an opposing second surface layer and a three-dimensional reticular structure bound between the first surface layer and the second surface layer, such that the moisturizing property of the biological fiber membrane is improved, thereby carrying more active ingredients. The present invention further provides a method for preparing a biological fiber membrane.

The present invention provides a biological fiber composite dressing. The biological fiber composite dressing includes: a cloth membrane having a first surface layer and an opposing second surface layer, wherein the cloth membrane has cloth membrane fibers; and a biological fiber membrane having a third surface layer and an opposing fourth surface layer, wherein the biological fiber membrane is formed by bacteria of the genus Gluconacetobacter, and the fourth surface layer is combined with the first surface layer, and a plurality of biological fibers being wound and combined with the cloth membrane fibers are extended along the fourth surface layer of the biological fiber membrane, such that the moisturizing effect of the dressing can be enhanced by the biological fiber membrane, thereby carrying more active ingredients.

The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as S1P.

The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells. Accordingly, late thrombosis and metal allergy may be reduced, and vascular restenosis in the stent region may be prevented, thereby making it possible to increase treatment effects of the bare metal stent.

The present disclosure provides click-crosslinked hydrogels and methods of use.

A hemostatic material includes a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets such as GPIb and H12 and, to achieve the object, provides a hemostatic material including a water-insoluble base and a lipid supported on a surface of the base, wherein the lipid includes one or two or more anionic lipids.

Compositions including a complex of fatty acids (e.g., including one or more C4 to C40 fatty acids, such as a C4 to C20 fatty acid) and one or more amino acids (and particularly one or more amino acids having electrically charged basic side chains, e.g., Arginine, Lysine, etc.) for use as an anti-pathogenic composition. In particular, described herein are compositions of decanoic acid:Arginine in which the decanoic acid and Arginine for a complex having a lamellar supramolecular structure.