Provided is a lyophilized implant configured to fit at or near a bone defect to promote bone growth, the lyophilized implant containing a biodegradable polymer in an amount of about 0.1 wt. % to about 20 wt. % of the implant, mineral particles in an amount from about 0.1 wt. % to about 75 wt. % of the implant, and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. Methods of making and using the implant are further provided.

Provided are ophthalmological implants comprising an active ingredient release system which, when the ophthalmological implant is implanted, delivers at least one pharmacological active ingredient, the active ingredient release system comprising at least one hydrogel as a matrix, the hydrogel forming a layer on an optical portion of the implant, binding covalently to the optical portion and being charged with the at least one active ingredient. Also provided are methods for producing the ophthalmological implant comprising the active ingredient release system.

Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.

The present invention generally relates to nitric oxide releasing pharmaceutical compositions and methods of using the same.

Devices for preventing and/or otherwise inhibiting biofilm formation include a lumen and/or a cavity coupled with a wall configured for holding oils, which leach through the wall of the devices to a surface, the oils at the surface creating a smooth surface coating.

The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.

The present invention provides a pharmaceutical composition for the lubrication of joints, the pharmaceutical composition comprising a non-ionic tonicity agent comprising a polyol, and liposomes comprising at least one membrane comprising at least one phospholipid (PL) selected from a glycerophospholipid (GPL), said GPL having two C12-C18 hydrocarbon chains, being the same or different, and sphingomyelin (SM) having a C12-C18 hydrocarbon chain, the pharmaceutical composition being essentially free of an additional pharmaceutically active agent, wherein the at least one membrane has a phase transition temperature in the range of about 20° C. to about 39° C. and the joint has a joint temperature which is above the phase transition temperature.

The present invention provides a biomaterial that is excellent in scratch resistance and retention in a case of being brought into contact with water. The biomaterial according to the embodiment of the present invention is a biomaterial including a neutral acyl lipid, at least one selected from the group consisting of a phospholipid and a quaternary ammonium salt, and a carboxyvinyl polymer. The neutral acyl lipid includes at least one selected from the group consisting of a neutral monoacyl lipid and a neutral diacyl lipid, and a content of the at least one selected from the group consisting of the neutral monoacyl lipid and the neutral diacyl lipid is 80% by mass to 100% by mass with respect to a total mass of the neutral acyl lipid.

Compositions including a complex of fatty acids (e.g., including one or more C4 to C40 fatty acids, such as a C4 to C20 fatty acid) and one or more amino acids (and particularly one or more amino acids having electrically charged basic side chains, e.g., Arginine, Lysine, etc.) for use as an anti-pathogenic composition. These compositions may include the complex of fatty acid:amino acid having a lamellar supramolecular structure. In particular, described herein are therapeutic compositions of undecylenic acid:Arginine forming a complex of undecylenic acid and Arginine.

The present disclosure provides click-crosslinked hydrogels and methods of use.