Cardiovascular prostheses having particulate structures that are adapted to induce modulated healing of damaged or diseased cardiovascular tissue and, thereby, associated structures, when administered thereto. The particulate structures include a biological component and a polymer component. The biological component is in the form of a composition and includes decellularized amniotic membrane and placental tissue. The biological composition can also include a plurality of exosomes derived from mesenchymal stem cells or embryonic stem cells. The polymer component includes poly(glycerol sebacate) (PGS).

Described herein are electrospun nanofiber structures and compositions configured to serve as TNT-based platforms for the delivery of an agent or cargo, such as genetic material. The structures can include a conductive nanofiber comprising a shell electrospun from an insulating polymer, wherein the shell comprises a plurality of nanochannels therethrough, a conductive element, and an agent contained within the shell. The conductive nanofiber can be configured to deliver the agent when exposed to an electric field. The agent can include a therapeutic agent, a prophylactic agent, or a diagnostic agent.

The present disclosure is concerned with magneto-patterned cell-laden hydrogel materials and methods of making and using those materials. The disclosed materials are useful for, among other things, repair of tissue defects, e.g., tissue at a tissue interface such as a bone-cartilage interface.

Disclosed herein are compositions to facilitate bone growth, formation, and/or repair. Methods of using and making the compositions are also disclosed.

The present invention relates to a dermal layer which is for grafting and has an improved graft survival rate, and a method for producing the same, wherein the dermal layer for grafting can be produced by filling a filling solution, including a DNA fragment mixture and chitosan, into an acellular dermal matrix from which cells have been removed. It was observed that the dermal layer for grafting produced in this manner, due to the filling solution filled therein and including a DNA fragment mixture and chitosan, increases the rate at which cells flow in from the tissue surrounding the graft and are fixed, and thereby alleviates an initial inflammatory reaction and promotes blending with the surrounding tissue.

A fiber assembly includes multiple fibers and nucleic acid fragments that crosslink the multiple fibers, and the fibers are microtubules or actin fibers.

Biocompatible polymer-coated transition metal chalcogenide (TMC) nanomaterials are provided herein. In particular, provided herein are two-dimensional polymer-coated TMC nanomaterials having excellent antimicrobial properties and biocompatibility, as well as methods of inhibiting microbiological growth on, or in, devices coated by or otherwise comprising the biocompatible polymer-coated transition metal chalcogenide (TMC) nanomaterials. In some cases, the biopolymer coating encapsulating the TMC nanomaterial comprises short synthetic single-stranded DNAs (ssDNAs). As described herein, ssDNA-encapsulated TMDCs exhibit no cytotoxicity against human cell lines at concentrations up to 0.25 mg/mL, but they exhibit exceptionally strong bactericidal activity against both gram-positive and gram-negative bacteria, including antibiotic-resistant Escherichia coli and a gram-positive methicillin-resistant Staphylococcus aureus (MRSA) strain. In other cases, TMDCs encapsulated by poly-L-lysine and Pluronic F77 display strong activity against multi drug resistance bacteria and form coatings that strongly inhibit bacterial biofilms, while TMDCs encapsulated by chitosan exhibit strong activity against fungi.

The invention provides polymer compositions for cell and drug delivery.

A medical product, preferably for use in treating, in particular filling and/or closing a bone cavity, wherein the product comprises a plurality of interconnected members, wherein each member has a peripheral boundary and the boundaries of adjacent members engage with one another. And a method for producing a medical product, preferably for use in treating, in particular filling and/or closing a bone cavity, wherein the product comprises a plurality of interconnected members, wherein each member has a peripheral boundary and the boundaries of adjacent members engage with one another.

Excessive or repeated activation of inflammatory and pro-coagulant mechanisms at the site of tissue injury contributes to the development scar tissue that can lead to intimal hyperplasia and fibrotic disease. It has been established that inhibition of the LYST protein is associated with reduced inflammatory responses and reduced platelet activation at the site of tissue damage. Compositions and methods for inhibition of the expression and function of the LYST protein are described. The compositions and methods can be useful for the modulation of immune processes that contribute to formation of neointima and fibroproliferative disorders by altering macrophage, platelet and natural killer cell function to create a pro-regenerative immune response.