Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.

The present invention relates to a topical composition of facilitating wound healing and reducing scars, which includes an inactivated culture of Lactobacillus species as an effective ingredient and can significantly facilitate wound healing as well as reducing scars, thereby can be applied to a method of facilitating wound healing and reducing scars.

Disclosed are compositions comprising Rhamnus prinoides (GESHO) extract or fragments thereof and methods of using Gesho extract for the inhibition of biofilm formation.

Disclosed are compositions, devices, kits, and methods for treatment of Enterobacteriaceae infection. Aspects of the present disclosure are directed to bacteriophage compositions comprising one or more of ES17, ES19, HP3, HP3.1, and HP3.2. Certain aspects of the disclosure are directed to compositions comprising (a) bacteriophage ES17 or bacteriophage ES19, (b) bacteriophage HP3, and (c) bacteriophage HP3.1. Also disclosed are compositions comprising bacteriophage HP 3.2. Further disclosed are devices and kits comprising such compositions and methods for use of such compositions in treatment and prevention of pathogenic E. coli infection.

The invention concerns a pharmaceutical composition comprising a platelet lysate and its use to treat a wound, an anal fissure, vaginal atrophy or a wrinkle.

An antimicrobial diapering device for one or more of inhibiting growth of a microorganism and killing a microorganism includes a diaper for diapering a user. The diaper comprises an outer layer, an inner layer, and a medial layer. The outer layer is substantially impervious to water. The inner layer is porous or wicking. The inner layer is impregnated with one or more of honey, an anthraquinone, and curcumin. The one or more of the honey, the anthraquinone, and the curcumin effect one or more of inhibiting growth of a microorganism and killing a microorganism. The medial layer is hydrophilic and is positioned between the outer layer and the inner layer. The medial layer absorbs moisture from urine and feces.

An improved dressing is presented which enables quicker wound closure and a lower anesthesia requirement, comprised of an improved prior-art skin-substitute. The improvements consist of variations in the thickness of the woven portion of the dressing, to increase wound adherence.

A periocular dressing includes a base layer composed of a nonwoven material; a top layer having a composition bound to a polyurethane film, the composition including a hydrogel with a percentage by weight of bacitracin, the top layer to come into contact with a user's skin; and a removable membrane secured over the top layer and to be removed; the polyurethane film of the top layer is adhesively secured to the base layer; and the top layer promotes vasoconstriction and antibacterial properties.

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

AlgaeAid is an inulin-integrating hydrogel dressing aimed at the treatment of second and third-degree burns and infected chronic wounds, which lack an optimal dressing. Currently, the vast majority of dressings for burns and chronic wounds are not optimal for all kinds of wounds. AlgaeAid's implementation of inulin separates it from the rest of the antibiotic hydrogels. The inulin allows for increased water retention within a hydrogel because it becomes osmotically active when combined with a liquid. As this property allows plants to remain hydrated and withstand dry and cold temperatures, increasing water retention. The flexibility that inulin provides makes AlgaeAid more universally applicable and allows for the treatment of wounds with more fluid expulsion which makes it effective against superbugs such as MRSA and can be readily sourced from a wide variety of algae and plant sources, including chicory, algae, and 35 other plant species.