A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more restoration agents, wherein the one or more restoration agents are suitable for a targeting position and are coated on the surface of the bioabsorbable stent. A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more bioabsorbable films, wherein the bioabsorbable films are loaded with restoration agents and/or drugs suitable for a targeting position.

A wound healing composition and method for treating acute and chronic wounds and skin conditions includes a wound healing composition or formulation including a mixture of buckwheat honey, methylglyoxal and bacitracin.

The invention relates to a bioactive bone repair substrate comprising granules obtainable by or obtained from a set solid state mixture of a calcium phosphate based bone repair matrix and a bioactive material, preferably granules having an average diameter between 25 and 10,000 μm.

A catheter configured to provide inherent antimicrobial properties includes a polyhydroxyalkanoate (PHA). In some embodiments, an extruded catheter body is fabricated of a PHA. In some embodiments, an extruded catheter body has an exterior layer containing PHA, an interior layer containing PHA, or both exterior and interior layers containing PHA. The PHA layer may be co-extruded with the catheter body. The PHA layer may be coating applied to the catheter body. Useful PHA materials to provide inherent antimicrobial properties include poly-4-hydroxybutyrate (P4HB) and copolymers of P4HB. The catheter may be an IV catheter, a urinary catheter, a dialysis catheter, or any other catheter introduced into a body lumen.

A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more restoration agents, wherein the one or more restoration agents are suitable for a targeting position and are coated on the surface of the bioabsorbable stent. A bioabsorbable stent system may comprise one or more bioabsorbable stents and one or more bioabsorbable films, wherein the bioabsorbable films are loaded with restoration agents and/or drugs suitable for a targeting position.

Disclosed a plant-derived exosome as well as a preparation method and an application thereof in preparation of drugs or scaffolds for animal tissue regeneration therapy. The preparation method includes: soaking and infiltrating any part of a natural plant with a 2-(N-morpholine) ethanesulfonic acid buffer solution; removing a supernatant; collecting a wet treated sample; refrigerating, centrifuging and extracting the sample to obtain apoplastic fluid, wherein the soaking and infiltrating method is as follows: vacuum supply is performed within 6-24 h after soaking for 2-5 times, vacuum supply time is independently 5-15 s each time, and interval time between two adjacent times of vacuum supply is independently 10 s-1 min; and centrifuging the apoplastic fluid at an ultra-high speed to obtain the plant-derived exosome, wherein ultra-high speed centrifugation conditions are as follows: centrifugal force is not lower than 100000 g, centrifugation time is 1-7 h, and a temperature is 0-4° C.

The present disclosure relates to birch bark extracts, methods of producing such extracts, stable pharmaceutical compositions containing such extracts and methods of using of such extracts. The birch bark extracts of the present disclosure contain triterpenes, which are known to improve wound healing.

The present invention relates in a first aspect to a method for coating a medical device suitable for implantation into an individual or for application on skin or mucosal tissue of an individual. Said method comprises the steps of applying to at least a portion of the surface of said device a coating layer whereby said coating layer comprises commensal microorganisms, like commensal bacteria, to form a biofilm on the at least portion of the surface of said medical device, further comprising the step of drying the biofilm coated on the surface of said medical device whereby the commensal microorganisms are eventually killed in case they were not applied as killed microorganisms in the step above, for obtaining a medical device having at least a portion of its surface coated with non-living commensal microorganisms In a further aspect, the coated medical devices obtainable by the method according to the present invention are provided. The coated medical devices according to the present invention are particularly useful in applications being mucosal tissue or a skin of an individual, like for use as an implant for dental use in the oral cavity. Finally, the present invention relates to the use of commensal bacteria like Streptococcus oralis for coating a medical device suitable for use as an implant into an individual or for application on skin or mucosal tissue of an individual.

A protein-modified PLGA microsphere can be used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves. It has been shown that the prepared tissue-engineered nerve effectively promotes nerve regeneration after peripheral nerve injury.

A biodegradable multi-purpose lens-shaped patch useful for healing and treatment of ocular conditions is disclosed. The patch is formed from a biodegradable carrier such as collagen from a mammalian source or a poly (DL-lactide co-glycolide) copolymer carrier. The carrier supports an amniotic extract and/or placental extract active ingredient. The lens-shaped patch may be shaped in the form of a conventional contact lens and it is applied to a corneal surface to enhance healing thereof. After a period of time ranging from one to thirty days, the patch degrades and completely dissolves and need not be removed. The degradation time can be adjusted by the use of crosslinking agents such as riboflavin.