The present disclosure relates to a coating with anti-adhesive properties (in order to repel or prevent bacterial or platelet adhesion) based on a naturally produced polymer. This polymer that has been extensively characterized and is produced by a marine bacteriumCyanothece sp. CCY 0110, at optimized production conditions to obtain increased amounts of polymer. Importantly, this strain is among the highly efficient polymer producers, secreting the polymer directly to the media, allowing the easy recovery of polymer with few purification steps, being a cost-effective product. The coating can be applied to medical devices or medical implants to prevent biofilm mediated infections thereof.

The present invention relates to a composition for preventing or treating stenosis, in which the composition includes brown algae extract, and more particularly to a composition for preventing or treating stenosis, in which the composition includes brown algae-derived polyphenol as an active ingredient, thereby providing excellent prevention or treatment effect on stenosis including tracheal stenosis, glottic stenosis, vascular stenosis, and the like.

An aqueous extract of Lawsonia inermis comprising forming an extraction from 1% to 20% of dried Lawsonia inermis leaves with water. The antibiotics polymyxin B, clindamycin, and gentamycin are each added to the water before or after extraction in the amount of 0.001% to 0.003%. After forming the aqueous extract of Lawsonia inermis, it has no antibiotic activity and the antibiotics are not detectable by chemical analysis. The aqueous extract of Lawsonia inermis is stable for at least 28 days for the topical treatment of wounds and has been stable up to two years in clinical testing. The aqueous extract of Lawsonia inermis extract is applied with a spray to the surface of the wound, followed by the application of an extract-soaked gauze dressing to the surface of the wound. The extract is effective on various types of wounds and also in healing wounds in patients who are not healing with traditional therapies.

An antimicrobial composition is provided. The antimicrobial composition includes a polymer matrix, an oil-derived component covalently bonded to the polymer matrix, and an oil-derived antimicrobial component non-covalently associated with at least one of the polymer matrix and the oil-derived component. Methods of making and using the antimicrobial composition are also provided.

A compression bandage is provided that includes a zinc oxide composition and/or one or more other therapeutic agents. In use, the bandage can be compression wrapped directly contacting a subjects skin for application of the zinc oxide composition and/or other therapeutic agents.

Disclosed a plant-derived exosome as well as a preparation method and an application thereof in preparation of drugs or scaffolds for animal tissue regeneration therapy. The preparation method includes: soaking and infiltrating any part of a natural plant with a 2-(N-morpholine) ethanesulfonic acid buffer solution; removing a supernatant; collecting a wet treated sample; refrigerating, centrifuging and extracting the sample to obtain apoplastic fluid, wherein the soaking and infiltrating method is as follows: vacuum supply is performed within 6-24 h after soaking for 2-5 times, vacuum supply time is independently 5-15 s each time, and interval time between two adjacent times of vacuum supply is independently 10 s-1 min; and centrifuging the apoplastic fluid at an ultra-high speed to obtain the plant-derived exosome, wherein ultra-high speed centrifugation conditions are as follows: centrifugal force is not lower than 100000 g, centrifugation time is 1-7 h, and a temperature is 0-4 C.

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phytopharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

This patent application describes a film developed from natural compounds to cover wounds, whose method of application is in the form of individual disposable packages, vials, syringes and/or others. This wound dressing provides a moist environment at the wound site allowing the occurrence of the autolytic debridement. The film incorporates bioactive agents such as acetylsalicylic acid, essential oils, plant extracts and others, which confer antibacterial, antifungal, anti-inflammatory, antioxidant and regenerative properties. The application method is also explored in order to simplify the life of patients, and to minimise pain and discomfort felt by them, during primary care treatment.

A tampon and delivery system for a pharmaceutical, holistic or medicinal component, includes: (1) a tampon having a generally cylindrical shape including a leading end and a cylindrical outer surface; (2) an outer delivery sheath applied to at least a portion of the cylindrical outer surface of the tampon, distal from the leading end (and preferably leaving the leading end exposed), where the outer delivery sheath comprises a formulation including (a) a water soluble polymer film carrier and (b) a pharmaceutical, holistic or medicinal component; and (3) an applicator containing the tampon and applied delivery sheath. Methods for preparation of the delivery system and methods of use are also disclosed.

The present application relates to an elastomeric article, such as a glove, comprising: (i) an elastomeric film comprising one or more film layers, and including an external surface and an internal surface, (ii) an antimicrobial agent that is effective against both beneficial and harmful microorganisms on the external surface of the elastomeric film, and (iii) a skin-protective agent selected from a probiotic, a prebiotic, or a combination thereof on the internal surface of the elastomeric film; wherein the inner surface of the film is free of an antimicrobially-effective amount of an antimicrobial agent that is effective against both beneficial and harmful microorganisms. The elastomeric articles may further comprise a barrier film layer that provides separation between the antimicrobial agent and the skin-protective agent. Also described are methods for the manufacture of such articles.