Provided is a pharmaceutical composition for treating a microbial imbalance, the composition comprising a pharmaceutically effective amount of at least one strain of probiotic bacteria, a pharmaceutically effective amount of cannabidiol and a pharmaceutically acceptable excipient. Further provided are feminine hygiene products comprising the composition and methods of use of the composition.

Disclosed herein is biocompatible composite material impregnated with antiinfective agents to reduce the rate of infection in patients with medical implants. Also disclosed herein is the utilization of super critical fluid (SCF) methodology to impregnate medical implant materials with antiinfective agents (e.g., antimicrobial, antibiofilm agents, etc.).

The present disclosure relates generally to materials and medical devices impregnated with antimicrobial compounds. More specifically, the materials are medical matrix materials comprising nanopores or nanochannels in which the antimicrobial compounds are disposed. In other embodiments, medical matrix materials comprises nanomaterials and antimicrobials distributed throughout the material. The materials described herein are useful for a broad spectrum of medical devices and consumer products. The present disclosure further provides methods of making the antimicrobial materials and medical devices disclosed herein.

Compositions and methods are provided for disrupting biofilms formed by microbial organisms. In accordance with one embodiment such compositions are used in conjunction with standard treatment for use on chronic wounds. In one embodiment the biofilm disrupting composition comprises a nuclease and aurine tricarboxylic acid. The biofilm disrupting compositions disclosed herein can be used in conjunction with a therapeutic pharmaceutical composition comprising standard antibiotics.

A method for production of anti-microbial orthodontic elastomeric ligatures is disclosed. The elastomeric ligatures are coated with an anti-microbial solution layer by layer. The coating solution comprising an anti-bacterial agent, a polymer and a solvent in the following ratio: 2 g anti-microbial agent, 4 g polymer and 200 mL solvent. The hypo-allergic latex-free orthodontic elastomeric ligatures with an internal diameter of 0.045 inches and external diameter of 0.115 inches are rinsed in distilled water, dried at 60° C. and sprayed with the anti-bacterial solution two times and dried for five minute. This process is repeated for five times and the elastomeric ligatures are dried at room temperature for 1 h.

Provided are compositions and methods for a scaffold coated with a primer coating and a mineral coating. Also provided is a composition for a scaffold having a mineral coating similar to bone. Also provided is a method for mineral coating a scaffold so as to promote mineral coating of the scaffold with a plate-like nanostructure and a carbonate-substituted, calcium-deficient hydroxyapatite phase.

Disclosed herein is a multicellular lay-up process. The process comprises the steps of: a) forming a core material, b) forming a capsule material, c) encapsulating the core with the capsule material, d) adding the capsule to a substrate, and e) exposing the capsule to at least one bioactivating agent.

Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

In at least one embodiment there is a wound application comprising at least one film applied over a wound comprising at least 1% green tea, and at least 0.01% sugar, wherein said film comprises a polymeric film comprising united chains and monomeric glucose points. In at least one other embodiment there is a wound application comprising a solution comprising at least trace amounts of colloidal silver, at least trace amounts of sodium chloride, at least trace amounts of dextrose; and water, wherein the colloidal silver, the sodium chloride and the dextrose are dissolved in water. In at least one other embodiment there is an application for treating a wound comprising both a solution comprising at least trace amounts of colloidal silver and a film comprising at least trace amounts of green tea applied over the solution on top of a wound.

Provided in this disclosure are chimeric peptides that include a spacer domain, the spacer domain itself, substrates (e.g., implants) coated with the chimeric peptides, and methods for making and using the coated substrates.