The invention relates to an antibacterial implant coating composition including a graft copolymer comprising a (meth)acrylic acid-based backbone and phosphonate side chains, wherein at least one phosphonate side chain is linked to a guanidine oligomer through an N—P bond.

Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

Disclosed herein are novel peptides that can comprise antimicrobial, antiviral, antifungal or antitumor activity when administered to a subject.

Biocompatible compositions, in particular for the preparation of a biodegradable coating for medical articles, include a biocompatible thickening polymer and a chitosan derivative comprising D-glucosamine units of the following formula (I):

##STR00001##

wherein X is an alditolic or aldonic polyol residue of the following formula (II):

##STR00002##

wherein: R is CH.sub.2 or CO; R1 is hydrogen, a monosaccharide moiety or an oligosaccharide moiety; R2 is OH or NHCOCH.sub.3.

The present invention also relates to uses of the disclosed compositions, to a kit of parts including a composition in powder form and to a method for the preparation of a biocompatible composition in gel form.

The biodegradable coating shows a good and long-lasting adhesion to the surface of a medical article and allows to improve both the coating operations and the effectiveness in preventing any biofilm formation on the medical article.

A medical wound healing accelerator having a body that is removably attached on a fixing pin, of an external fixator for fractures, that is insertable into a bone through skin is provided. The device can further include a plurality of light source units arranged on one surface of the body to emit light and provide a beneficial effect to the wound, and a controller electrically connected to the light source units. An osteomyelitis treatment device having an insert that is insertable into an osteomyelitis part in a human body, and a plurality of light-emitting members provided to the insert to emit light is also provided. The plurality of light-emitting members can be spaced apart from each other, and a part of the insert can be cut or bent to correspond to the shape of the osteomyelitis part.

The present invention is a self-cleaning catheter designed to impede the development of biofilm within the catheter and provide a mechanism for removing biofilm within the catheter during use by a patient. The self-cleaning catheter includes an outer shell enclosing a urine lumen. The urine lumen has the ability to be opened and closed with a urine lumen closure device and is formed with a plurality of micro ports and a plurality of macro wash ports. At least one antimicrobial lumen is affixed to the exterior of and in fluid communication with the urine lumen at the plurality of micro ports. Similarly, at least one wash lumen is affixed to the exterior of and in fluid communication with the urine lumen at the plurality of macro wash ports. Antimicrobial solutions and wash solutions are introduced into the urine lumen by the antimicrobial lumen and wash lumen respectively, even during use.

A drug-releasing polymer composition is disclosed. It may include a major component, which may be ethylene vinyl acetate, and may further include at least one or two release-modifying materials, and may further include at least one or two drugs. The release-modifying materials may be polyethylene glycol and polycaprolactone. The drugs may be minocycline and rifampin. There may be an interaction such that in the presence of two different release-modifying materials, drug release may be greater than with either release-modifying material alone. There may be an interaction such that in the presence of two drugs, drug release may be greater than with either drug alone, and antibacterial performance may be enhanced. Release durations as long as two months are possible. In addition, the composition can be provided on a medical device that is configured for implanting in body tissue for an extended time period.

Tubular conduits are provided which have an outer surface and/or an inner surface functionalized with at least one antimicrobial peptide having the sequence X.sub.1X.sub.2WVX.sub.3IWVX.sub.4X.sub.5, wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 are independently selected from K and R and wherein each amino acid is independently in the D or L configuration, or a salt or solvate thereof. The tubular conduits are preferably made of biodegradable polymeric material. The functionalization of the tubular conduits with the at least one antimicrobial peptide prevents contamination caused by Gram negative bacteria, Gram positive bacteria, fungi, yeasts and/or viruses.

Organosilicon quaternary ammonium compounds, their formulations, including powdered and solid formulations, and methods of use to treat infections in humans and animals.

A heat treatment method for improving the mechanical property and the biofunctional stability of a magnesium alloy is provided, comprising: (1) fully annealing an original cold-drawn magnesium alloy AZ31; (2) polishing a surface of the magnesium alloy AZ31 from the step (1) by a waterproof abrasive paper; (3) heating the magnesium alloy AZ31 obtained from the step (2) to a temperature of 330° C. to 350° C. and keeping the temperature for 3 to 4 hours; and (4) cooling the magnesium alloy AZ31 obtained from the step (3) to room temperature. A method for manufacturing a small-peptide-coated biomaterial and an application of the small-peptide-coated biomaterial are further provided.