Microcatheters and methods for modifying and delivering suspended particles to target bodily parts (e.g., of a cardiovascular system). Embolization microcatheters and uses thereof in performing local embolization procedures, involving modifying flow characteristics (momentum) of suspensions during delivery. Applicable for delivering embolization material in a small blood vessel towards a target bodily part, and for performing local embolizations in small blood vessels feeding (possibly, cancerous) target bodily parts, thereby forming emboli therein, while preventing or minimizing non-target embolization. An exemplary catheter includes: a tubular wall with proximal and distal wall ends, and a lumen extending therebetween, opened and configured to allow passage of a suspension to a distal outlet; the distal outlet shaped or/and sized to allow passage of both a suspension fluid and particles; a proximal outlet configured to allow passage of the suspension fluid without particles and to block passage of the particles, during delivery of the suspension.

A balloon catheter is disclosed having a balloon at a distal portion of a catheter shaft and on a surface of the balloon are elongate bodies which are crystals of a water-insoluble drug having independent long axes. The balloon in a deflated state has a plurality of wing portions in a circumferential direction of the balloon, and a circumferential surface portion along a circumferential direction of the catheter shaft, the plurality of wing portions being folded along the circumferential direction of the balloon. A surface of the circumferential surface portion which faces the plurality of wing portions that are folded has a region in which tip portions are not in contact with the surface of the balloon or with other elongate bodies, and a surface which faces the plurality of wing portions that are folded which faces an outer circumferential side has a region in which the tip portions are in contact with the surface of the balloon or with the other elongate bodies.

Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.

An absorbable stent includes an absorbable matrix. The matrix includes a number of wave-shaped rings connected by connection units and arranged in an axial direction. The wave-shaped ring includes a number of waves arranged in a circumferential direction. A peak, a valley and a support connecting the peak and the valley form the wave. Two adjacent wave-shaped rings and the connection unit form a closed side supporting unit. The matrix has a volume of 4 μm to 40 μm per unit blood vessel area. The absorbable stent has sufficient radial supporting strength of no less than 55 kPa for clinical applications. Moreover, the volume of the matrix per unit blood vessel area is less than volumes of existing stents. When the absorbable stent and existing stents are made of the same material, the absorbable stent has a shorter degradation and absorption cycle.

An endoluminal device includes a composite yarn with a polymer yarn and an alloy wire. The polymer yarn includes a biodegradable polymer, and the alloy wire includes a biocompatible alloy. An endoluminal device can include a plurality of polymer yarns and at least one alloy wire, in which the polymer yarns include a biodegradable polymer, and the least one alloy wire includes a biocompatible alloy. A surgical system or kit includes an endoluminal device and a delivery instrument.

An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.

Compositions comprising electrospun fibers and active (e.g. pharmaceutical) agents encapsulated thereto are provided. Further, articles and methods of use of the fibers, including, but not limited to coating of medical tubing, are provided.

The present invention relates to a pharmaceutical composition for intravascular delivery of a therapeutic agent, such as paclitaxel, rapamycin, or an analog thereof. The composition includes the therapeutic agent and a biocompatible solvent, such as glycofurol. The composition can aid tissue penetration by the therapeutic agent. A catheter assembly that protects the pharmaceutical composition from the surroundings can be used for its intravascular delivery.

The invention relates to balloon coatings and their use in delivering drugs via a drug-eluting balloon. The delivery can be, e.g., to a vessel wall.

The present invention provides a core-shell microparticle comprising a biodegradable polymer with at least two or more surface cavities for use in the treatment of vascular disease, wherein the shell further comprises one or more drugs. The present invention further provides a core-shell microparticle which can be used for such treatments, the microparticle comprising a biodegradable polymer with at least two or more surface cavities, wherein the shell further comprises one or more drugs, wherein the one or more drugs are selected from anti-inflammatory drugs, immunosuppressants, anti-proliferative drugs, anti-coagulants and combinations thereof.