Disclosed is an antithrombotic coating composition and a coating method using the same. The composition is highly hydrophilic and biocompatible, thereby enabling a thin and flexible coating layer. The composition is suitably used for coating vascular catheters, stents, guide wires, and other invasive medical devices.

The present disclosure is directed to a method of preparing an osteogenic bone graft. The method includes introducing an anticoagulant compound into a volume of cellular material including a mononuclear cell population from the intramedullary canal of a long bone; collecting an effluent including the volume of cellular material containing the anticoagulant compound at a collection point; separating a concentrated cell fraction from the effluent, the concentrated cell fraction including the mononuclear cell population and the anticoagulant compound; and preparing an osteogenic bone graft from the concentrated cell fraction.

Described herein are substrate coatings.

The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or portion thereof.

The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

The invention relates to a cannula (1) for injecting a fluid (F1) into a body cavity (5), comprising: a main lumen (LP) for the fluid to flow in a first direction; an accessory reperfusion lumen (LA) comprising an outlet (20′) for discharging the fluid in a second direction; and a device for positioning the cannula in the cavity, the device comprising a stop (41) which can move along an auxiliary lumen (LX) and be deployed in the cavity in order to lock the cannula in position in the cavity,
the outlet (30′) of the auxiliary lumen being arranged at a distance (d) from the outlet (20′) of the accessory reperfusion lumen such that when the cannula is locked in position in the cavity, the outlet (20′) of the accessory reperfusion lumen (LA) is oriented in the cavity such that the collected fluid is discharged in the second direction.

The present invention provides a composition which is used to form a cured film that is disposed on a medical device and a medical device with a cured film, which are capable of suppressing both the adhesion of platelets and the adhesion of cells. A composition according to the embodiment of the present invention is a composition which is used to form a cured film that is disposed on a medical device, and which contains a compound represented by Formula (1).

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A biomimetic tissue scaffold for repairing an elongated tissue in need of repair can comprise a plurality of coiled flexible polymeric ribbons having a surface on which is formed an array of nanofibers, the ribbons forming a tubular body defining a first open end in which a first end of the elongated tissue is receivable, a second open end in which a second end of the elongated tissue is receivable, and a lumen extending between the first and second open ends.

A method for passivating a biomaterial surface includes modifying proteinaceous material disposed at the biomaterial surface. The passivation may be effectuated by exposing the biomaterial surface to therapeutic electrical energy in the presence of blood or plasma.

The present invention is directed to improved coatings and coating methods for medical devices.