A disulfide cross-linked hyaluronic acid gelatin for postoperative abdominal (pelvic) adhesion prevention and a preparation method therefor, wherein the content of disulfide cross-linked hyaluronic acid of the disulfide cross-linked hyaluronic acid gelatin is among 3-8 mg/mL. The disulfide cross-linked hyaluronic acid gelatin not only has favorable biocompatibility, but also has favorable prevention effects on tissue adhesions when being used for postoperative abdominal (pelvic) adhesion prevention.

The disclosure provides for methods of sealing of decellularized and recellularized engineered organ grafts, thereby providing a reinforced (fortified) decellularized and recellularized engineered organ graft.

An entirely or partially implantable medical product with a negatively charged surface for repulsing bacteria has a superficially bonded substance with a permanently negative excess charge, which substance is inert against cells of the human body and the bacteria contained therein.

One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated grail including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.

The application discloses a use of nanofiber membrane in the preparation of medical apparatus for anti-adhesion after a surgery, wherein small molecule drug, inhibiting vascular endothelial growth factor and/or inhibiting vascular endothelial growth factor receptor, is loaded into the nanofiber membrane. The nanofiber membrane provided in the present application has the following advantages: it has good biocompatibility, excellent mechanical properties, excellent flexibility and smoothness when exposed to water, good air permeability, and has the ability to effectively prevent adhesion between the heart and surrounding tissues. In addition, it can also be applied to other surgical operations, such as prevention of adhesions in the abdominal cavity, pelvis, and tendons.

The present invention relates to a composition comprising an amino acid-modified polymer, a carboxypolysaccharide, and may further include a metal ion for anti-adhesion and vector application. More specifically, the invention relates to a thermosensitive composition having enhanced mechanical and improved water-erosion resistant properties for efficiently preventing tissue adhesions and can serve as a vector with bio-compatible, bio-degradable/absorbable, and in-vivo sustainable properties.

Synthetic amino acid-modified polymers and methods of making the same and using the same are disclosed. The synthetic amino acid-modified polymers possess distinct thermosensitive, improved water-erosion resistant, and enhanced mechanical properties, and are suitable of reducing or preventing formation of postoperative tissue adhesions. Additionally, the amino acid-modified polymers can also be used as a vector to deliver pharmaceutically active agents.

The invention concerns methods of delivering a hydrogel to the heart, comprising: introducing a hydrogel composition into a subject, said hydrogel comprising components mixed prior to introduction; the introducing being performed such that the hydrogel composition resides between the epicardium and the pericardium of the subject. In some embodiments, the injection is performed using a syringe or catheter.

An adhesion prevention material consisting of: (1) a first agent comprising a gelatin derivative, the gelatin derivative (a) including a structure represented by the following formula, GltnNH—CHR.sup.1R.sup.2, in the formula, Gltn represents a gelatin residue, R.sup.1 represents an alkyl group with 5 to 17 carbon atoms, and R.sup.2 represents a hydrogen atom or an alkyl group with 5 to 17 carbon atoms; (b) having imino group/amino group (molar ratio) of 1/99 to 30/70; and (c) having a weight average molecular weight of 10,000 to 50,000; and (2) a second agent comprising a crosslinker for the gelatin derivative.

The present invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine, and a manufacturing method therefor, the method comprising: (1) a step for adjusting each of the pH values of a hyaluronic acid-calcium salt and a polylysine aqueous solution to 8.4 or higher, and then mixing the hyaluronic acid-calcium salt and the polylysine aqueous solution to obtain a mixture liquid; and (2) obtaining a wound dressing from the mixture liquid obtained in Step (1).