It relates to a nonwoven fabric membrane for topical use on the skin, which comprises polymeric nanofibres and an active agent in an amount from 25 to 80% by weight with respect to the total weight of the nonwoven fabric membrane, wherein the active agent is soluble in a suitable biocompatible solvent system, and wherein the membrane is capable of releasing the active agent immediately when the membrane is contacted with an appropriate amount of the suitable solvent biocompatible system in which the active agent is completely solubilised. It also relates to a process for the preparation of the nonwoven fabric membrane, to a cosmetic or sanitary product and a kit comprising them and to their therapeutic and cosmetic uses.

The present invention relates to an injectable pharmaceutical formulation for the alleviation or reduction of joint irritation or for the reduction of worsening of existing joint inflammation, formulated for intra-articular injection comprising an active polyol ingredient, which polyol active ingredient is xylitol. Use of an intra-articular injectable formulations for the treatment of joint diseases or conditions including arthritis is described.

Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.

A coating material including a bio-absorbable cross-linked material and a cellular uptake inhibitor. The bio-absorbable cross-linked material includes two or more fatty acids cross-linked into a substantially random configuration by ester bonds. The coating material may be adhered to a medical device. A medical device system including a medical device and a coating is also included.

Dermal filler hydrogel compositions, methods of making them, and methods of using them to treat soft tissue conditions, such as wrinkles, are provided. The compositions contain a crosslinked hyaluronic acid-based polymer and one or more additional ingredients, and are stable to sterilization by heat and/or pressure treatment. The additional ingredients include vasoconstrictive agents, antioxidant agents, such as a ascorbic acid agents, and/or anesthetic agents.

The present invention relates to an injectable pharmaceutical formulation for the alleviation or reduction of joint irritation or for the reduction of worsening of existing joint inflammation, formulated for intra-articular injection comprising an active polyol ingredient, which polyol active ingredient is xylitol. Use of an intra-articular injectable formulations for the treatment of joint diseases or conditions including arthritis is described.

A method of reducing the deterioration of a wetted hydrophilic coating caused by sterilization by radiation is provided. The method comprises the step of incorporating a thiosulfate anion and a buffer into the wetting hydrophilic coating comprising water. Some embodiments of the invention relate to a wetted hydrophilic coating, a wetting agent, a package comprising a wetted hydrophilic coating, and a method of sterilizing a wetted hydrophilic coating.

The invention concerns the use of an antimicrobial composition comprising metallic silver and metallic ruthenium as well as at least one vitamin or at least one vitamin derivative for the topical treatment or prevention of skin, skin adnexa or mucosa diseases which are caused by infection with at least one microorganism. The invention also concerns a bandaging material or patch comprising an antimicrobial composition which comprises metallic silver and metallic ruthenium as well as at least one vitamin or at least one vitamin derivative. The antimicrobial composition (AgXX) has a broad-spectrum effect against bacteria (a: E. coli) and fungi (b: Pathogen is yeast and c: Penicillium).

a) Escherichia coli (additionally silver (Ag) as control),

b) Candida parapsilosis,

c) Penicillium notatum;

A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.

A medical device including a substrate and a hydrophilic polymer layer and satisfying the following conditions: (1) that the hydrophilic polymer layer is on at least a part of the substrate; (2) that the hydrophilic polymer layer contains: a hydrophilic polymer having an acidic group; and a compound having an acidic group and a ring structure; and (3) that a time during which a liquid film is retained on the surface of the medical device (a liquid film retention time) is 10 seconds or more after the medical device is stationarily immersed in a phosphate buffer solution, pulled up from the phosphate buffer solution, and retained in the air. The present invention provides a medical device in which a surface of a substrate is hydrophilized, and a method for manufacturing same by a simple method.